About Orbis Medicines

Orbis Medicines is a pioneering biotech company transforming drug discovery with cutting-edge chemistry and data-driven approaches to develop oral alternatives to injectable biologics. Orbis’ nGen platform designs macrocycles with oral bioavailability by combining AI technologies with automated synthesis and high-throughput screening of real compounds.

Orbis Medicines have an established R&D site in Copenhagen that includes a state-of-the-art laboratory and a team of +20 experienced technical professionals and scientists.

Orbis Medicines has just been awarded a 2025 Endpoints 11 title as one of biopharma's most exciting start-ups.

This marks the first time a Nordic biotech has received this honor – highlighting the disruptive potential of Orbis Medicines. With a recent EUR 90 million Series A funding round, led by top-tier investors such as NEA, Eli Lilly, Cormorant, the Export and Investment Fund of Denmark and founding investors Novo Holdings and Forbion, Orbis Medicines are well-positioned for significant growth and long-term success. The confidence of these investors validates the potential to bring groundbreaking therapies to the market.

Orbis Medicines offer the excitement of a start-up, opportunities for professional growth, and the opportunity to be at the forefront of biotech innovation. Your ideas and contributions will shape the future of medicine. Please visit the website for more details; www.orbismedicines.com

About the role

We are seeking a highly skilled Senior Scientist for the Screening Biology department, to play a key role in the development, automation, and execution of advanced high-throughput screening strategies at Orbis Medicines.

In this role, you will develop robust and scalable biological assays by combining strong scientific knowledge with hands-on laboratory work. This position offers the opportunity to shape screening approaches at the core of Orbis’ discovery engine in close collaboration with the Platform Chemistry and AI & Computational Drug Design departments.

This is a hands-on senior role, where you will:

• Actively perform experiments and troubleshoot assays
• Drive the implementation of screening technologies and automated workflows
• Optimize the lab-in-the-loop cycle

Your main tasks will include :

• Design, develop, and implement biochemical and cellular assays for both screening and hit validation
• Establish assays suitable for automation and high-throughput screening
• Drive assay robustness, reproducibility, and data quality
• Lead and support DEL screening campaigns at CROs
• Apply biophysical methods (e.g. SPR, DSF, or similar) for hit validation and characterization of target–

compound interactions

• Collaborate closely with Chemistry teams to align screening strategies with compound libraries
• Analyze and interpret complex screening and biophysical datasets and translate data into actionable

insights for project team

• Managing screening data and applying the FAIR data principles

Scientific leadership & collaboration

• Act as scientific lead within Screening Biology
• Set screening strategy and long-term assay platform direction in collaboration with VP of Platform

Chemistry

• Mentor and develop scientists and technicians
• Provide scientific input to portfolio and project decisions
• Communicate results and recommendations to senior leadership
• Lead a small cross-functional team (Screening Biology, Platform Chemistry, Computational Chemistry,

and AI/Data Science) to ensure alignment across hit identification, hit validation, and progression of

hits to advanced hits

Your Skills and Expertise

You hold a PhD in a relevant field combined with several years of relevant industry experience, including strong hands-on experience with assay development and high throughput screening, including development of cellular screening assays. You have experience working with automation and liquid handling systems and preferably experience with DEL screening.

Experience with biophysical techniques such as SPR, DSF, ITC or similar methods is considered an advantage.

You enjoy working hands-on in the laboratory and are able to combine strong scientific depth with practical execution. You thrive in an innovative, fast-paced environment and are motivated by contributing directly to experimental work and data generation.

Application

Please apply via the link.

Orbis Medicines collaborates with DEDENROTH on this recruitment. Please contact Mia Danielsen to express your interest or if you have any questions about the role or the process.

Phone: +45 26178142 / Email: md@dedenroth-consulting.com