About Karius
Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions.
Summary
We are seeking a Senior Manager to lead Karius’s growing Manufacturing and Technical Operations team. This role oversees the full end-to-end manufacturing lifecycle, including production planning, sourcing, inventory management, reagent and kit manufacturing, and quality control testing for existing products. The Senior Manager will also drive the development of manufacturing infrastructure, new production processes, qualification procedures, and tracking systems that enhance the scalability and robustness of reagent manufacturing. Key responsibilities include designing and establishing a dedicated manufacturing infrastructure, coordinating cross-functional activities to ensure operational goals are consistently achieved, and providing technical leadership to support and optimize reagent manufacturing workflows. The ideal candidate brings strong operational excellence, deep technical expertise in molecular biology, and the ability to build and scale robust, compliant manufacturing processes that support clinical, analytical, and commercial needs.
Why Should You Join Us?
Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale.
Reports to: Senior Director, Assay Development and Manufacturing
Location: Redwood City, CA
Primary Responsibilities
What’s Fun About the Job?
Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters.
Travel: No regular travel is required.
Physical Requirements
Subject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is generally performed in an office, lab or clinical environment.
Position Requirements
- Ph.D. in Biological Sciences or a related field with 8-10 years of experience in Development, Biotech, Technical Operations, or Reagent Manufacturing, including 3–5 years of people management experience.
Extensive experience in assay development within molecular diagnostics or related applications in LDT or RUO settings; IVD experience is highly preferred.
- Extensive hands-on experience with Next-Generation Sequencing (NGS) and nucleic acid–based reagent development or manufacturing is required.
- Demonstrated ability to lead and develop a growing team, with strong interpersonal skills and the ability to build effective working relationships across internal and external partners.
- Strong organizational skills, attention to detail, and a proven ability to manage multiple projects, timelines, and priorities in a fast-paced environment.
- Prior experience in a startup or high-growth company is highly preferred.
Personal Qualifications
Disclaimer
The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius.
Equal Opportunity Employer
At Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at recruiting@kariusdx.com and we will accommodate qualified individuals with disabilities.
