Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

The Opportunity We are seeking an exceptional Head of Biology to lead the scientific strategy and execution that will realize the full potential of the Manifold platform. You will own the creation of a differentiated pipeline of tissue-targeted therapeutics that are delivered directly to target tissue via novel receptor portals that have been discovered through our platform combining AI-design with in vivo data at scale. You will directly lead our discovery biology and pharmacology teams, while also serving as the accountable leader for 1-2 drug-discovery matrix project teams from product concept through IND.

As a member of our R&D leadership team, you will set pipeline and portal prioritization strategy and represent Manifold's science with potential business partners, investors, and KOLs. Our initial focus is CNS: brain-shuttled mAbs and oligonucleotides leveraging novel BBB portals, with expansion opportunities into other tissue targets and modalities.

Key Responsibilities

Qualifications

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds. Base Salary Range: $240,000-340,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This Role Is Eligible For

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.