About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Job Title: Sr. Director, People & Culture Business Partner

Department: People & Culture

Location: Princeton, NJ (On-site 4 days/week)

Reports To: VP, People & Culture

Job Overview Kardigan is seeking an experienced and strategic Sr. Director, People & Culture Business Partner to serve as a trusted advisor to senior leaders across multiple functions and lead People & Culture initiatives at our Princeton, NJ site. This role will be instrumental in shaping and executing workforce strategies that align with Kardigan’s mission and values, fostering a high-performance, inclusive, and purpose-driven culture.

Essential Duties And Responsibilities

• Serve as the People & Culture Business Partner for Kardigan’s Princeton location, ensuring alignment with company-wide People & Culture strategies and values.
• Act as a strategic business partner to senior leaders across Development, Technical Operations, and other functions, providing guidance on organizational design, talent strategy, and change management.
• Lead partner with P&C site leader on workforce planning efforts, including headcount forecasting, succession planning, and organizational effectiveness initiatives.

Qualifications And Preferred Qualifications

• Bachelor’s degree required, advanced degree in Human Resources, Organizational Development, or related field preferred.
• Minimum of 10+ years of progressive HR experience, with at least 5 years in a strategic business partner role supporting senior leadership. Experience in Biotech/Pharma is highly desirable.
• Proven experience in workforce planning, employee relations, and organizational development.
• Strong interpersonal communication skills with the ability to influence and build trust across all levels of the organization.
• Demonstrated ability to thrive in a fast-paced, start-up environment.
• Passion for building inclusive, mission-driven cultures that prioritize patients and people.

Exact Compensation may vary based on skills, experience and location.

Pay range

$241,000 - $314,000 USD