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About the Company

At GSL, our mission is to revolutionise biomarker discovery and development by harnessing the power of machine learning (ML). We are dedicated to improving diagnostics and advancing treatment options in rare, cardiac, and neurodegenerative disease. Through cutting-edge ML algorithms, we develop panels of biomarkers that can be used to diagnose, stratify and monitor patients across the entire clinical development pathway.

Our commitment is to empower healthcare professionals with the tools they need to provide precise diagnoses, enable the development of next-generation treatments, and improve accuracy levels across the entire clinical development pathway, ultimately saving lives and enhancing the quality of care worldwide.

Our Culture and Values

Within GSL, we have a culture and value set that isn’t just a paragraph or a mission statement. Our team all share a passion of wanting to make a real difference in our work, and to go above and beyond what is expected of us. We will always use our collective knowledge to advise where appropriate and add as much value as possible to the work that we undertake. In order to achieve this our teams will always focus on the below methods to ensure we always deliver the best possible outcomes for our customers and patients.

• Innovation
  • We are dedicated to pushing the boundaries of technology and embracing continuous innovation in the fields of mass spectrometry and ML
• Accuracy
  • Precision and accuracy are something we strive for in every aspect of our work. We therefore strive to provide the most reliable and clinically meaningful results to aid in diagnoses and treatments.
• Empowerment
  • We empower healthcare professionals with tools that enhance their capabilities, leading to better patient care and outcomes.
• Collaboration
  • Collaboration is key to our success. We work closely with healthcare providers, researchers, and partners to co-create solutions that address the complex challenges of patient care.
• Patient Centric
  • We put patients first, focusing on improving their lives by providing solutions that enable early detection and personalized treatments.
• Continuous Learning
  • We encourage a culture of continuous learning and growth, enabling our team to stay at the forefront of our field.
• Global Impact
  • Our commitment extends beyond borders, striving to make a global impact by democratizing access to advanced diagnostics.
• Service
  • We take pride in offering the best customer service and experience, and we have implemented a range of strategies and principles to ensure we deliver our commitments.
• Quality Assurance
  • We are dedicated to maintaining the highest possible quality standards, ensuring that our ML and Core Lab services consistently meets or exceeds the expectations of the medical community and regulatory bodies.

Job Description

• Lead on projects within GSL’s CoreLabs program
• Validate targeted proteomic assays to clinical standard (CLIA, GLP)
• Independently applies scientific principles to achieve project objectives, including the design and execution of complex experiments, and analysis and interpretation of data under limited supervision
• Assessing viability and feasibility of new assays
• Execute project deliverables for biomarker studies in clinical trials by project scope of work and within sponsor-specific timelines.
• Manage day-to-day operational aspects of clinical biomarker projects.
• Assist in preparation and adherence to trial documents i.e., Project Protocols, Data Transmittal Forms etc.
• Ensure project documentation are complete, current, and stored appropriately.
• Manage key documents/processes i.e., Project Management Plan, Communication Plan, Escalation Plan, Risk Management Plan, and appropriate Clinical Trial Management Systems (CTMS).
• Identification of scope out quests – working with appropriate team(s) to revise work orders to meet changing needs and requirements.
• Prepare metrics reporting for client and senior management.
• Manage Core Lab Resources and ensure timely delivery of analysis.
• Working alongside the head of commercial – support of pre-sales process – methodologies, procedures & pipelines.
• Creating and Contributing to Standard Operating Procedures of the overall service, and individual projects.
• Direct Customer engagement
• Liaise with external study teams to ensure smooth delivery of project metrics – this may include attendance at progress meetings as required.
• Some domestic and international travel will be required.
• Contribute to laboratory duties to maintain smooth laboratory operation
• Troubleshoot equipment issues
• Adhere to laboratory safety protocols and human tissue sample handling procedures
• Carry out any other duties as are within the scope, spirit and purpose of the job as requested by the Line Manager.

Skills/Experience Requirements

• PhD in biochemistry/related subject desirable
• 3+ years’ experience in mass spectrometry operation and method development
• Experience using Waters triple quadrupole machinery essential
• Quality Assurance/Compliance in clinical trials settings; Experience in Clinical trials/mass spectrometry in a clinical environment desirable

Person Specification

Essential

• Degree in a relevant biomedical subject
• Research or clinical laboratory experience in handling human samples
• Mass spectrometry experience in equipment operation, method development, and data analysis
• Excellent spoken and written English
• Good organisational skills and attention to detail
• Ability to analyse and write up data
• Good communication and interpersonal skills (both verbal and written)
• IT skills - Word, Excel, Access, PowerPoint
• Ability to troubleshoot issues with equipment and ability to keep accurate records
• A full commitment to translational research the ability to troubleshoot and the insight to know when to ask for assistance
• Willingness to learn and adapt to new techniques
• Ability to work collaboratively and as part of a team but be able to function independently and effectively

Desirable

• Clinical laboratory work experience
• Knowledge and experience developing analytical assays