PUXANO

PUXANO is a platform-based Contract Research Organization (CRO) that integrates AI-driven protein design and engineering with experimental structure-based protein research, including cryo-electron microscopy (cryo-EM). They offer proprietary Design-to-Structure and Gene-to-Structure workflows to accelerate the development of novel vaccines, protein therapeutics, and biopesticides. Their platform enhances protein sequence analysis, design, expression, purification, biophysical characterization, and high-resolution structure determination. Key technologies include site-specific antigen design, generating soluble analogues of membrane proteins, and the PUXANO speciality grid portfolio for cryo-EM sample preparation. PUXANO aims to be a long-term partner in early-stage drug development and crop protection solutions.

AIBiotechnologyCROCryo-EMProtein DesignStructure-BasedTherapeuticsVaccinespuxano.com

PUXANO

AIBiotechnologyCROCryo-EMProtein DesignStructure-BasedTherapeuticsVaccinespuxano.com

HQGent, BE

Team Size7

Open Jobs1

Total Funding-

Latest FundraiseUnknown

Join the Team

Senior Scientist: Machine Learning (protein structure/design/function)

HybridGhent, Flemish Region, BE

Hybrid • Ghent, Flemish Region, BE

PUXANO is looking for a highly motivated Senior Scientist with a hands-on mindset to build and lead a team developing next-generation AI solutions in structural biology and protein engineering.

In this role, you’ll work at the intersection of machine learning, protein design, and structure-to-function prediction. The successful candidate will focus on the development and fine-tuning of open-source models for protein structure prediction and protein design similar as OpenFold, ProteinMPNN and Genie.

What you'll do:

Model Development & Improvement

Teeming tracks opportunities at over 24,000 AI startups, then works with you to find (and land) the one you'll love.

Mobile Developer

InternshipNew York, US

Internship • New York, US

AI Researcher

Part-timeManchester, GB

Part-time • Manchester, GB

AI Researcher

Full-timeLondon, GB

Full-time • London, GB

Machine Learning Engineer

Full-timeJerusalem

Full-time • Jerusalem

Software Engineer

InternshipHamburg, DE

Internship • Hamburg, DE

Technical Writer

ContractAustin, US

Contract • Austin, US

TL;DR

Company Overview

Funding Track Record

Founders

What we do

PUXANO

AIBiotechnologyCROCryo-EMProtein DesignStructure-BasedTherapeuticsVaccinespuxano.com

PUXANO

AIBiotechnologyCROCryo-EMProtein DesignStructure-BasedTherapeuticsVaccinespuxano.com

HQGent, BE

Team Size7

Open Jobs1

Total Funding-

Latest FundraiseUnknown

Join the Team

Senior Scientist: Machine Learning (protein structure/design/function)

HybridGhent, Flemish Region, BE

Hybrid • Ghent, Flemish Region, BE

PUXANO is looking for a highly motivated Senior Scientist with a hands-on mindset to build and lead a team developing next-generation AI solutions in structural biology and protein engineering.

What you'll do:

Model Development & Improvement

Teeming tracks opportunities at over 24,000 AI startups, then works with you to find (and land) the one you'll love.

Mobile Developer

InternshipNew York, US

Internship • New York, US

AI Researcher

Part-timeManchester, GB

Part-time • Manchester, GB

AI Researcher

Full-timeLondon, GB

Full-time • London, GB

Machine Learning Engineer

Full-timeJerusalem

Full-time • Jerusalem

Software Engineer

InternshipHamburg, DE

Internship • Hamburg, DE

Technical Writer

ContractAustin, US

Contract • Austin, US

Conduct research on protein de novo prediction and protein design/engineering models, with an emphasis on the development of novel de novo prediction or diffusion-based protein design models or the enhancement of existing open-source models such as OpenFold and Genie.

Develop and implement algorithms to improve the accuracy and efficiency of protein structure predictions and protein design, including finding novel routes to score predictions to guide selection for experimental research.

Collaborate with experimental teams to integrate model improvements into PUXANO’s validation platform, including cryo-EM image processing

Develop and evaluate structure-to-function prediction algorithms

Research & Innovation

Stay up to date with advances in protein prediction, design, and engineering
Propose and lead innovative ML/DL research projects, internally and with external partners
Contribute to advancing PUXANO’s Gene-to-Structure and Design-to-Structure capabilities

Collaboration & Communication

Work closely with Pharma and Biotech partners
Communicate complex technical concepts to both technical and non-technical audiences
Contribute to grant writing and funding proposals

Ph.D. in Computer Science, Physics, Computational Biology, Bioinformatics, Structural Biology, or related field
Strong background in machine learning / deep learning, ideally applied to protein science
Experience training models on HPC / GPU clusters (e.g. EuroHPC)
Proficiency in Python, PyTorch, TensorFlow, and related tools
Excellent problem-solving skills and a track record of innovative research
Strong communication skills and ability to work in a fast-paced, interdisciplinary environment

Familiarity with cryo-electron microscopy (cryoEM)
Knowledge of structural bioinformatics and molecular dynamics simulations
Experience in Pharma or Biotech

Your CV
A GitHub link showcasing relevant computational work (please not that c andidates without demonstrable ML/DL expertise (via GitHub or scientific publications) will not be considered.)
A cover letter
Contact details for three references (including technical references)

Apply via: careers@puxano.com 🗓 Application deadline: February 15, 2026