Our Momentum In August 2024, Outpace Bio secured an oversubscribed $144 million Series B financing, led by RA Capital Management and supported by a premier syndicate of life science investors. This funding accelerates our pipeline of programmed T cell therapies, including our lead candidate OPB-101, a mesothelin-specific chimeric antigen receptor (CAR) T cell enhanced by Outpace’s proprietary OUTSMART™, OUTLAST™, OUTSPACER™, and OUTSAFE™ technologies. OPB-101 is advancing toward IND clearance and first dosing in 2025 for patients with advanced platinum-resistant ovarian cancers. The Series B investment also supports the expansion of our pipeline, enabling us to develop additional transformative therapies leveraging our innovative plug-and-play technology platform.

We are seeking a Senior Research Associate or Scientist I to join the viral vector production team at Outpace Bio. In this role, you will apply your scientific training and technical expertise to produce, purify, and characterize lentivirus for our cell and gene therapy applications. Working collaboratively with our Immunology, In vivo, and Cloning teams, you will ensure timely delivery of high-quality viral vectors while contributing to the development of novel viral assays and scale-up process development and improvement.

Successful candidates will bring strong technical skills in mammalian cell culture, viral vector systems, viral vector process development, viral downstream purification, and analytical techniques including flow cytometry and molecular quantitation methods. We seek motivated, detail-oriented scientists who can work independently, troubleshoot technical challenges, and optimize protocols to advance our research programs. If you are a collaborative team player with strong problem-solving skills and enthusiasm for translating research into therapeutic impact, you will thrive in our fast-paced startup environment.

Responsibilities (Position responsibilities may include, but are not limited to):

• Produce and characterize lentivirus supporting multiple Outpace research and pipeline programs
• Design and execute optimization experiments to improve viral titers, purity, and production efficiency
• Support scale-up of lentiviral production for process development and preclinical in vivo studies
• Perform and optimize functional titer and genome quantitation assays (flow cytometry, ddPCR/dPCR)
• Contribute to the development of improved upstream and downstream vector production and purification methodologies
• Contribute to experiment design, data analysis, and presentation of results in internal meetings
• Contribute to authoring or reviewing protocols, reports, or regulatory filings.

Qualifications (Required)

• Ability to work independently on experimental design, execution, and troubleshooting
• Proficiency in mammalian cell culture and aseptic technique
• Hands-on experience with small-scale lentivirus production (adherent or suspension systems)
• Working knowledge of chromatography and filtration principles, downstream bioprocessing, and process scale-up
• Experience operating chromatography systems (AKTA or equivalent)
• Experience with filtration operations including UF/DF and depth filtration
• Highly organized with strong attention to detail and data quality
• Ability to learn new protocols quickly and apply critical thinking to problem-solving
• Effective scientific communication skills with ability to discuss results and collaborate with team members
• Experience measuring viral titer by flow cytometry and ddPCR/digital PCR
• Hands-on experience with transfection and transduction protocols
• Experience safely handling lentivirus under BSL-2 conditions
• 3+ years of research experience with mammalian cell culture systems

Qualifications (Preferred)

• Master's or PhD in Virology, Molecular Biology, Immunology, Cell Biology, Gene Therapy, or related field; alternatively, Bachelor's degree with substantial position-relevant research experience in academic or industry setting
• Lentivirus process development in suspension culture formats (96-well, 24-well, shake flask, and 1-5L bio-reactor scales)
• Downstream viral vector processing including tangential flow filtration (TFF) and chromatography-based purification
• Familiarity with molecular biology techniques including nucleic acid isolation, quantification, and PCR-based methods
• Experience with mammalian cell culture in bioreactor systems
• Experience in a startup or fast-paced biotech setting
• Experience with Electronic Lab Notebook (ELN) systems (Benchling)
• Ability to manage multiple projects, prioritize workflow, meet deadlines, and collaborate effectively in cross-functional teams
• Familiarity with other viral vector platforms (gamma retrovirus, AAV)

$90,000 - $130,000 a year

This position is a Senior Research Associate or Scientist I level position with a compensation range of $90,000-$105,000 for a Senior Research Associate level and $111,000-$130,000 for a Scientist I level. Actual compensation is dependent upon current market data, experience, and pay parity at Outpace.

The salary range is based on Outpace Bio's reasonable estimate of base salary for this role at the time of posting. Actual base salary will be based on a variety of factors including skills, experience, and other related factors permitted by law.

Working at Outpace offers an exciting opportunity to contribute to groundbreaking research that has the potential to transform the lives of people around the world.

Outpace Bio Total Rewards Full time employees and their eligible dependents may enroll in Outpace's medical, dental, vision, life insurance, disability, flexible spending account, health savings account, commuter benefits, legal benefits, and 401k plan which includes an employer match. In addition, employees may receive stock option grants to be outlined in their offer of employment and a performance bonus. Outpace employees enjoy flexible PTO, paid sick leave which complies with local requirements, and fifteen paid holidays plus a winter shutdown. Outpace also offers a generous paid parental leave policy to all regular full-time employees.

Outpace Bio is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.

Applicants must be authorized to work in the United States. If you are legally authorized to work in the United States now, or in the future without any form of sponsorship, we encourage you to apply. Outpace Bio does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Outpace Bio or its employees is strictly prohibited unless contacted directly by Outpace Bio's internal team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Outpace Bio and will not owe any referral or other fees.