This role focuses on supporting the technological development of novel and existing screening platforms, alongside coordinating the implementation of new technologies and Standard Operating Procedures (SOPs) in alignment with company-wide goals. With growing experience, the successful candidate will become a key point of contact for stakeholders, supporting the smooth operation of the wider Functional Genomics (FG) department and R&D.

Your key responsibilities will include:

• Execute genetic screens aimed at identifying programming factors in human iPSCs and mammalian cell lines, taking responsibility for sample tracking and quality control (QC).
• Perform experimental work aimed to develop and expand the team's capabilities.
• Perform molecular biology techniques and molecular/cell phenotyping assays, including PCR, ddPCR, and flow cytometry.
• Coordinate work tasks and manage team resources. Monitor day-to-day lab activities, maintain tissue culture reagent stock levels, ensure equipment is properly maintained, and adhere strictly to good lab practice standards.
• Increasingly with experience, train other staff members as required.
• Contribute to the development and implementation of new technologies, workflows, and operational infrastructure.
• Document and report activities in a precise, timely, and exhaustive fashion. Communicate outcomes of experimental work to team and department both in oral and written form.
• Draft key technical documentation, including Tech Transfers, SOPs, and Data Packages.
• Stay up to date with key aspects of genetic engineering, vector assembly, cell line engineering processes, and next-generation sequencing.

You…

• Will have a minimum Bachelor's degree in a relevant field of Biological Science (or equivalent experience) and proven experience in a skilled research assistant role within a Discovery Screening function.
• Have the ability to operate autonomously with minimal, high-level direction.
• A meticulous approach and attention to detail are required.
• Proven ability to communicate research and project outputs effectively (written and verbally).

With essential experience in...

• Strong practical and theoretical background in mammalian cell culture and engineering/gene editing.
• Practical and theoretical background in human iPSC culture and engineering/gene editing.
• Well-rounded and practical experience of molecular biology techniques (e.g., PCR) and molecular/cell phenotyping assays (e.g. ddPCR).
• Experience in executing and optimising large scale screening protocols.
• Good knowledge and experience of high-throughput genomic screening technologies and automated tissue culture workflows (e.g. 96/384 well plates).

and possibly...

• Experience executing flow cytometry experiments (e.g., choosing fluorophores, compensation controls) and analysing/interpreting FACS data.
• Knowledge and experience with reporting via electronic lab notebooks (e.g. Benchling) and sample tracking.

More reasons to join us: bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.

We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.

Creativity and open minds are encouraged for everyone to contribute to the success of the company.

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