Who are we? Arbor Biotechnologies™, a next-generation gene editing company based in Cambridge, MA, is advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions – from the ultra-rare to the most common genetic diseases. The company’s unique suite of optimized gene editors goes beyond the limitations of early editing technologies to unlock access to new gene targets and has fueled a robust pipeline of first-in-class assets focused on diseases of high unmet need. With Arbor’s lead program, ABO-101 for the treatment of primary hyperoxaluria type 1, progressing into clinical trials, the company continues to focus their research and development efforts on genomic diseases of the liver and CNS for which there are no existing functional cures. For more information, please visit: arbor.bio.

Who are you? Passionate, determined, and accountable. Curious, resourceful, innovative, forward thinking, and resilient. Authentic, humble, open-minded and puts team above self. At Arbor, our people embrace these qualities, so if this sounds like you then please read on!

About The Role We are seeking a highly motivated Project Manager/Senior Project Manager to drive cross-functional program execution while delivering strategic, data-driven insights that shape portfolio and investment decisions. This is a hybrid role for someone who thrives at the intersection of science, business, and operations —combining rigorous project management fundamentals with analytical capabilities such as forecasting, scenario modeling, competitive intelligence, and strategic evaluation. You will play a critical role in translating breakthrough science into development-ready programs and ensuring that teams operate with clarity, alignment, and forward momentum.

Why This Role Matters This position sits at the center of Arbor’s innovation engine.

You Will

• Ensure our scientific teams have the structure, alignment, and visibility needed to deliver on high priority R&D milestones.
• Provide leadership with actionable insights that drive portfolio decisions and resource allocation.
• Help build and mature Arbor’s project and portfolio management discipline as the company scales.

Your work will directly accelerate program progress and influence how Arbor invests in its most promising scientific opportunities.

What You Can Expect Program & Project Leadership

• Lead planning, execution, and tracking for cross-functional R&D programs, partnering with Research, Development, CMC, Regulatory, Clinical, and other stakeholders.
• Build, own, and maintain integrated program plans, timelines, dependencies, and risk registers.
• Orchestrate core team meetings, governance discussions, and executive updates—providing clarity, surfacing issues early, and enabling timely decisions.
• Proactively identify risks, resource constraints, and trade-offs; recommend mitigation strategies informed by scenario and sensitivity analysis.
• Ensure program objectives remain aligned with broader portfolio strategy and corporate priorities.

Business & Strategic Analytics

• Develop and maintain forecasting models for timelines, resources, milestones, probability-adjusted scenarios, and decision paths.
• Conduct competitive intelligence (CI) and landscape monitoring; integrate internal and external insights into program and portfolio recommendations.
• Create dashboards, analyses, and materials that provide leadership with clear, data-driven decision support.
• Partner with program leads and leadership to evaluate program prioritization, investment cases, and strategic options.

Cross-Functional Enablement & Process Excellence

• Serve as a translator between scientific teams and business leadership - distilling complex concepts into clear plans, insights, and narratives.
• Drive consistency in project management tools, templates, and processes; contribute to maturing our PMO and portfolio capabilities.
• Enable a culture of transparency, accountability, and cross-functional collaboration.

Required What You Bring:

• MBA, MS, or equivalent advanced training providing strong analytical and/or financial modeling foundations.
• Bachelor’s degree in a scientific discipline (e.g., biology, biochemistry, bioengineering, or related field).
• A minimum of 5 years’ of relevant experience
• Proven project management experience in a complex, fast moving, cross-functional environment.
• Demonstrated analytical capabilities: forecasting, scenario modeling, financial or strategic analysis.
• Ability to collaborate effectively with scientific teams while communicating clearly with nontechnical audiences.
• Strong organizational, critical thinking, and problem solving skills.

Preferred

• Experience working within biotechnology, pharmaceutical R&D, or life sciences.
• Background supporting research through early development programs.
• Familiarity with portfolio management, competitive intelligence, or corporate strategy in a biotech setting.
• Experience building dashboards or working with project/portfolio management systems.

Attributes for Success

• Highly organized with a bias toward clarity, simplification, and proactive communication.
• Comfortable navigating ambiguity and driving alignment among cross-functional teams.
• Strong analytical mindset with the ability to distill complexity into actionable insights.
• Collaborative and confident—willing to challenge assumptions constructively.
• Deep curiosity and passion for translating breakthrough science into impactful medicines.

Our Values Our values govern the work we do at Arbor, and we’re hoping that they resonate as strongly with you as they do with us!

• Purposeful Action: Start with The Why
• Bold Resilience: Adopt a Growth Mindset
• Humble Authenticity: Start in the Heart

We promote diversity and inclusion not just in our recruitment processes, but in everything we do. We’re an equal opportunity employer and we will continue to ensure our recruitment process is free of bias and our workplace is inclusive, positive, and free of discrimination and respecting of all backgrounds and beliefs.