
Axle Informatics is a bioscience and technology company that accelerates discovery and enhances organizational outcomes through innovative research, technology, and healthcare solutions. They provide…

Axle Informatics is a bioscience and technology company that accelerates discovery and enhances organizational outcomes through innovative research, technology, and healthcare solutions. They provide…
Location: Rockville / North Bethesda, Maryland
Sector: Bioscience & research-focused technology
Core offerings: Research support, data science/AI–ML, research data management, healthcare identity/authentication
Notable program involvement: Participant in All of Us Research Program CLAD initiative (associated $30M award)
Leadership: Co-founder & CEO Vidya Chari (Vidya Chari Sharma)
Research data management, secure identity/authentication for research collaboration, and analytics for biomedical research and public health.
2002
Biotechnology Research
$30M
Associated award for the All of Us Research Program CLAD initiative referenced on company news pages
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(ID: 2025-0846)
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Axle
is seeking a talented Pharmacoepidemiologist to join our team to support projects at the NIH’s National Center for Advancing Translational Sciences (NCATS) . In this role, you will collaborate with clinical and data scientists, methodologists, and software engineers to develop and execute exemplar causal inference studies. You will work as a subject matter expert to create a real-world evidence (RWE) methods decision tree; support master protocol development; and support development of gold-standard guides and methodologies for conducting best practices causal inference research. You will: design, execute, and analyze studies using the National Clinical Cohort Collaborative (N3C) data; review and recommend strategies for selecting study designs to answer causal inference questions; help establish, and implement appropriate analytic value sets.
Benefits We Offer:
Overview:
The ideal candidate for the Pharmacoepidemiologist position is a highly skilled professional with a Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics, Causal Inference or
related
field. This person has experience with electronic health record and/or claims data and a strong understanding of observational study principles including: missing data handling methods; temporal research questions (cross-sectional, longitudinal); causal contrast of interest (e.g., intent-to-treat, per-protocol); effect measure of interest (e.g., risk ratio, hazard ratio); and
estimands
(e.g., average treatment effect, average treatment effect in the treated) of interest. Your research experience includes one or more of the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods, realized in multiple primary-author publications. Fluency with coding languages and tools is expected (i.e. SQL, Python, and R).
Responsibilities:
Required Qualifications:
Preferred Qualifications:
Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com
This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.
#IND
Salary Range: $135,000 USD - $140,000 USD
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Serve as SME for RWE causal inference studies.
Design and execute studies with N3C EHR data considering the following: extent of missing data; missing data handling methods; temporal component of research studies (i.e. cross-sectional, longitudinal); the causal contrast of interest (e.g., intent-to-treat, per-protocol); the effect measure of interest (e.g., risk ratio, hazard ratio); and
estimand
(e.g., average treatment effect, average treatment effect in the treated) of interest.
Review and recommend strategies for selecting individuals in clinical cohorts.
Ensure the highest data quality and minimization of bias.
Use tools and languages such as Python, R, SQL, and Spark.
Help establish and implement appropriate analytic value sets.
Collaboratively produce extensive documentation (i.e. through training material, research protocols, open data sources such as repositories and/or methodological and research papers).
Work closely with data science and software developer teams to articulate technical methods and implement decision tool strategies.
Extract and transform clinical data from clinical trial and observational studies.
Participate in project meetings, provide updates on progress, challenges, and mitigation strategies.
Actively engage in key relevant meetings and keep abreast of emerging best practices and methods.
Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics or related field.
Experience with the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods realized in at least 2 primary-author peer-reviewed publications, or equivalent.
Ability to independently conduct statistical analysis with analytic software tools (e.g. Python, R, SQL,
MatchIt
/
WeightIt
, Matplotlib, Lifelines,
SKLearn
, GT-summary,
statsmodels
, Survey).
Fluent in coding languages and tools (e.g. Python, R, SQL, Spark).
Strong communication and collaboration skills, with the ability to work effectively in a multidisciplinary team.