The Opportunity:

We are seeking an exceptional Senior Director of Biotherapeutics to help guide and mature Manifold's discovery, characterization, and production of shuttled therapeutics. This role spans discovery and nonclinical development, including optimal utilization of internal protein science expertise to run high-throughput in vivo screens, bioengineering strategies to generate best-in-class molecules, and oversight of external contract manufacturing organizations (CDMOs) to develop processes and manufacture drug product for clinical trials.

As a key member of our leadership team, you will contribute to high-level strategy and help build internal resources to support our ambitious growth plans. This is a unique opportunity to shape the future of a cutting-edge biotechnology company while working with a collaborative, innovative team.

Key Responsibilities:

Team Management & Development

• Manage and mentor internal protein sciences and protein engineering teams
• Foster team growth and development through effective leadership and mentorship
• Build and focus teams in a capital-efficient manner to support current and future pipeline needs

Program Execution

• Support the discovery and characterization of shuttled therapeutics via 1-2 matrix project teams, serving as biotherapeutics lead or project lead
• Map out critical path activities through IND-enabling studies and ensure key activities are resourced and executed efficiently
• Set and implement strategy for developability assessment and early-stage de-risking
• Prepare and present data packages for partnering discussions and investor presentations

Strategic Leadership

• Contribute to high-level strategy and key objectives for discovery and development of shuttled therapeutics
• Understand and support strategic growth plans of the organization, helping to build and focus internal resources for success
• Establish development candidate nomination criteria for novel biotherapeutics with particular focus on developability, balancing timelines, budget, and risk
• Identify and outline opportunities for backup molecule discovery and selection

External Partnerships

• Serve as Manifold's protein therapeutic representative for partnered program(s), providing clear communication with biotherapeutics counterparts at partner organizations
• Manage relationships with CDMOs and related CROs, including selection, contract negotiations, and maintaining timelines/budgets

Qualifications:

Required Experience & Skills

Preferred Qualifications

• Knowledge of neuroscience
• Understanding of high-throughput screening or bioanalytical technologies
• Experience with generative AI models for protein and/or oligonucleotide design

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.