
Grafton Sciences is focused on building physical superintelligence to accelerate scientific discovery. Their mission is to create systems capable of autonomous scientific discovery, utilizing tools that expand our capabilities. They are developing an at-home early detection platform for cancer, leveraging advances in synthetic biology and nanotechnology. With a $42.5 million contract from ARPA-H, Grafton aims to detect over 48 tumors at Stage I, representing a significant portion of the global cancer burden. Their approach integrates computational modeling, automated experimentation, and materials engineering, positioning them as leaders in the field of disease detection and scientific innovation.

Grafton Sciences is focused on building physical superintelligence to accelerate scientific discovery. Their mission is to create systems capable of autonomous scientific discovery, utilizing tools that expand our capabilities. They are developing an at-home early detection platform for cancer, leveraging advances in synthetic biology and nanotechnology. With a $42.5 million contract from ARPA-H, Grafton aims to detect over 48 tumors at Stage I, representing a significant portion of the global cancer burden. Their approach integrates computational modeling, automated experimentation, and materials engineering, positioning them as leaders in the field of disease detection and scientific innovation.
About Grafton Sciences
We’re building AI systems with general physical ability — the capacity to experiment, engineer, or manufacture anything. We believe achieving this is a key step towards building superintelligence. With deep technical roots and real-world progress at scale (e.g., a $42M NIH project), we’re pushing the frontier of physical AI. Joining us means inventing from first principles, owning real systems end-to-end, and helping build a capability the world has never had before.
About the Role
We're seeking a Security & Platform Lead to architect and ship a new developer-facing platform from the ground up. You will own the full stack: desktop application architecture, security model, integration framework, and the infrastructure. This is a foundational role; you'll ship a working product in weeks, and build security into the architecture from day one.
You will own the security model end-to-end, ship foundational platform primitives, and operationalize the system for correctness, security, and reliability as software becomes increasingly coupled to real-world outcomes. This role sits at the center of the stack and will shape the platform’s architecture, trust boundaries, and long-term scalability.
Responsibilities
Qualifications
Above all, we look for candidates who can demonstrate world-class excellence.
Compensation
We offer competitive salary, meaningful equity, and benefits.