Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position Manifold Bio is seeking a creative and driven expert in protein analytics and antibody characterization to join our Protein Sciences team and help expand the frontiers of shuttle-enabled drug delivery. In this role, you will drive innovative projects to assess protein-protein interactions and molecule characteristics. You'll develop screening methodologies and rational design approaches for determining affinities of epitope-paratope pairs in high throughput formats. You’ll also establish techniques to characterize protein stability and developability to guide lead selection and optimization The data that you generate will inform molecule selection and Test Article formulations for Manifold’s unique multiplexed in vivo screening platform. This position is central to advancing internal therapeutic programs and building datasets that support partnering and platform expansion. You'll generate critical data for cross-functional program teams and serve as a core Protein Sciences team member, bringing strong protein analytics expertise and collaborative skills to develop Manifold's next generation of targeted biologics.

Responsibilities

• Think deeply about and drive projects to investigate binding kinetics of therapeutic proteins to their target of interest.
• Generate and deeply characterize individual binders to inform test article formulation strategies.
• Build pipelines to screen hundreds to thousands of binders, analyze data, and generate plots for dissemination to the broader team.
• Utilize Manifold’s in vivo multiplexing capabilities to assess in vivo performance characterized molecules.
• Generate, interpret, and communicate high-quality, decision-enabling data to inform program strategy and therapeutic design.
• Collaborate cross-functionally to progress therapeutic programs.
• Maintain clear documentation, share findings in team meetings, and contribute to strategic discussions on program direction and platform development.

Required Qualifications

• PhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or related field
• Proven expertise in protein analytics and protein-protein interactions utilizing techniques such as BLI, SPR, ELISA, aSEC, DLS, and CE-SDS/cIEF.
• Proficiency in protein expression and characterization laboratory techniques
• Strong analytical skills and creative problem-solving abilities, with the capacity to develop novel approaches and drive innovation in complex scientific challenges
• Adaptable and proactive mindset with a track record of productivity and successfully translating innovative ideas into meaningful outcomes
• Strong communication skills and collaborative working style

Preferred Qualifications

• Industry experience developing therapeutic antibodies
• Previous experience working on brain shuttle technologies
• Background working with data from protein mass spectrometry
• Experience with performing analysis on large data sets of protein-protein interactions and integrating data analysis in automated workflows
• Familiarity with computational modeling of protein-protein interactions

This Role Might Be Perfect For You If… You are curious and passionate about science and drug discovery and want to work with a fast-moving team that values scientific boldness and innovation. This role requires deep technical expertise combined with a willingness to work thoughtfully and quickly to solve scientific challenges in a collaborative manner. You value an experimental approach and generating high-quality data to empower rapid, data-driven decision-making, with a commitment to meet or beat critical deadlines. You should be a team player who is also proactive and resourceful.

If you’re excited to use unique protein technologies to shape an innovative drug development strategy, build meaningful industry partnerships, and contribute directly to our mission of advancing breakthrough treatments, please apply! We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.