Scientist / Senior Scientist – Antibody Analytical Characterization
Prellis Biologics is advancing next-generation antibody therapeutics by integrating machine learning, scalable biology, and proprietary 3D-printed human lymph node organoids. We are expanding our platform into complex antibody modalities to develop innovative biologic medicines, with programs spanning
obesity, inflammation and immunology (I&I), and oncology
.
Position Summary:
We are seeking a highly motivated
Scientist or Senior Scientist
with a strong background in
therapeutic antibody characterization
to join our therapeutics team. The successful candidate will contribute to the analytical assessment of
monoclonal antibodies, bispecifics, and Fc-fusion proteins
, supporting drug development through detailed
biophysical and biochemical characterization
.
Key Responsibilities:
- Perform comprehensive
analytical characterization
of therapeutic mAbs, bispecifics, and Fc-fusion proteins/antigens.
- Conduct biophysical and stability assessments including
Tm, Tagg (Uncle), Size, AC-SINS, HIC, cIEF, aSEC, and BVP assays
.
Qualifications:
- MS or PhD
in Biochemistry, Chemistry, Molecular Biology, or a related field.
- 2–3 years of industry experience
with characterization of therapeutic antibodies, bispecifics, or Fc-fusion proteins.
- Strong hands-on experience with
Tm, Tagg (Uncle), Size, AC-SINS, HIC, cIEF, aSEC, and BVP assays
.
- Demonstrated ability to work independently and collaboratively in a team environment.
- Excellent
problem-solving, organizational, and communication skills
.
Preferred Skills:
- Experience in
antibody developability, stability profiling, or comparability studies
.
- Optional/Preferred:
LC-MS-based antibody characterization
(intact, subunit, peptide mapping) for detailed structural analysis.
- Knowledge of
regulatory expectations
for therapeutic biologics characterization.
At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being.
The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
Application deadline
Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.
