
Talus Bio turns previously undruggable transcription factors into therapeutic targets by directly measuring and modulating the cellular regulome. The company’s MARMOT platform combines functional proteomics, automated biology, synthetic chemistry, and machine learning to generate large-scale functional datasets in living human cells and design candidate molecules. Talus Bio focuses on drug discovery for oncology and other diseases driven by genome regulators, including autoimmunity and neurodegeneration. The company partners with pharmaceutical and biotechnology organizations to advance therapeutics.

Talus Bio turns previously undruggable transcription factors into therapeutic targets by directly measuring and modulating the cellular regulome. The company’s MARMOT platform combines functional proteomics, automated biology, synthetic chemistry, and machine learning to generate large-scale functional datasets in living human cells and design candidate molecules. Talus Bio focuses on drug discovery for oncology and other diseases driven by genome regulators, including autoimmunity and neurodegeneration. The company partners with pharmaceutical and biotechnology organizations to advance therapeutics.
Founded: 2020
Headquarters: Seattle, WA
Focus: Drug discovery targeting transcription factors via regulome profiling
Platform: MARMOT native regulome profiling (functional proteomics + ML + chemistry)
Recent financing: Seed+ round led by Two Bear Capital (announced Aug 20, 2024)
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Drug discovery for diseases driven by genome regulators (oncology, rare disease, immune dysfunction, neurodegeneration).
2020
Biotechnology Research
9750000
Seed round closed; reported raise of $9.75M with participation from investors including NFX and Y Combinator.
11200000
Seed+ financing announced with participation from WRF Capital, NFX, YC Continuity Fund, FundersClub VC, and BoxOne Ventures.
“Two Bear Capital led the Aug 20, 2024 Seed+ round; earlier investors include NFX and Y Combinator.”
Talus Bioscience is seeking highly motivated summer interns to join our team! These paid summer internships provide opportunities to own and participate in challenging and impactful business-critical projects at a thriving biotech start-up!
Internships are approximately 3-months (summer) in duration and the roles are performed on-site at our Seattle, WA laboratory under the supervision of PhD scientists. Relocation assistance benefits are not available for this job posting. Interns will participate in all lab meetings and team meetings, as well as Talus Bio social and team-building events. All positions require excellent communication and interpersonal skills, and successful candidates will complement our culture and align with our core values. At the end of the internship, interns will present their project to the entire company.
Internship Description: The Drug Discovery team is seeking a summer intern to participate in research and drug discovery in the area of Oncology. The successful candidate will learn and apply cellular/molecular biology to validate targets and hits as well as screen compounds coming from our proteomics platform. The intern in this role will be expected to make intellectual as well as technical contributions to the team.
Target Applicant: Undergraduate or graduate student with 2+ years of lab experience; preferred majors: cell biology, cancer biology, molecular biology or biochemistry
Note: this internship is available only to those with legal authorization to work in the US
Status: Full-time role (40 hours/week); hourly (non-exempt) position
Required Skills and Experience: Biology-related research experience especially in RT-qPCR assays, basic knowledge of molecular and cancer biology or cancer pharmacology-related fields
Assignments: Work with the team to learn and conduct studies using in vitro & cell-based assays, as well as preparing samples for evaluation with our proteomics platform
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