Job Title:  Research Associate/Senior Research Associate

Department:  Protein Sciences

Reports To:  Head of Protein Sciences

Contract Type:  Full time

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About the Company

T-Therapeutics is a next-generation T cell receptor (TCR) company spun out from the University of Cambridge. The company was created to harness the power of T cell biology, to create safe and effective treatments for cancer and autoimmune disease. T-Therapeutics’ experienced team combines world-leading expertise in mouse genome engineering, single cell genomics, biopharmaceutical drug development, machine-learning and structural biology, anchored in a culture of creativity and collaboration.

T-Therapeutics is developing ‘optimal’ TCR bispecific therapeutics using its proprietary OpTiMus® discovery platform, that provides an almost unlimited source of unique, antigen-specific human TCRs. The company is developing a pipeline of first-in-class drugs that are intended to become transformative medicines, reshaping the clinical landscape for patients with cancer or autoimmune diseases.

Summary:

We are seeking a highly motivated and skilled Research Associate/Senior Research Associate to join our Protein Sciences team. The ideal candidate will have a background in protein purification, biophysical characterisation, and analysis. Experience working with novel format biologics and/or with analytical equipment such as a HPLC would be desirable. The successful candidate will contribute to the purification, and characterization of recombinant proteins to support our drug discovery and development programmes. This role offers an excellent opportunity to work within a fast-paced, cutting-edge research environment and contribute to the advancement of novel therapeutics.

Key Responsibilities:

• Support all projects through the purification of proteins expressed from bacterial and mammalian cell culture.
• Characterise purified material using standard techniques (UV-vis, SDS-PAGE, SEC-HPLC, icIEF etc).
• Contribute to the development of purification and analytical methods.
• Communicate findings to colleagues and peers.
• Collaborate with other scientists across different teams.

Qualifications:

• Advanced degree (BSc, MSc, or equivalent with industry experience) in Biochemistry, Biophysics, or a related field.
• Experience in protein purification and characterisation techniques
• Experience with the AKTA automated purification systems and Unicorn software are desirable.
• Experience with a variety of protein analysis techniques, including gel electrophoresis and chromatography is essential.
• Knowledge of analytics techniques such as HPLC-SEC would be desirable.
• Ability to work independently and as part of a team.
• Strong analytical and problem-solving skills.