Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries and in vitro human lymph node cocultures for generating antigen-specific B-cells. We are seeking a highly motivated Research Associate - Senior Research Associate, Cell Culture/Cell Line Development , to join our Antibody Screening team. The successful candidate will contribute to the maintenance, scale-up, and development of mammalian cell lines for biologics discovery. This role will involve hands-on laboratory work, data analysis, and close collaboration with cross-functional teams.

Key Responsibilities:

• Perform aseptic mammalian cell culture across multiple cell lines in parallel (e.g., CHO, HEK293, etc.)
• Support routine maintenance, passaging, expansion, and cryopreservation of cell lines to ensure a reliable supply of high-quality cells for downstream applications
• Support cell line development workflows, including transfection, clone screening, and selection
• Contribute to in vitro assay execution, as needed, to support antibody screening and downstream characterization efforts
• Maintain meticulous experimental records and effectively communicate findings in internal meetings
• Contribute to process optimization for improved productivity and product quality

Minimum Qualifications:

• B.S in Molecular Biology, Chemistry, Immunology, Biotechnology, or related life science field with 2+ years of relevant experience.
• 1–2 years of hands-on laboratory experience in mammalian cell culture is required (industry setting preferred). Demonstrated proficiency with aseptic technique.
• Familiarity with cell line development techniques (stable and transient transfection, clone selection, characterization, etc.).
• Strong organizational and time management skills to contribute to multiple projects in a fast-paced environment.
• Ability to work independently and as part of a collaborative team.
• Experience with small-scale bioreactor systems is a strong plus.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.