Manifold Bio is a biotechnology company leveraging its m Design platform to revolutionize drug discovery through in vivo biologics design. The company combines a unique 100-plex pooled in vivo…
AI-guided Protein DesignBiologics DesignDrug DiscoveryIn VivoMultiplexingTissue-targeted Medicinesmanifold.bio
Manifold Bio
Manifold Bio is a biotechnology company leveraging its m Design platform to revolutionize drug discovery through in vivo biologics design. The company combines a unique 100-plex pooled in vivo…
AI-guided Protein DesignBiologics DesignDrug DiscoveryIn VivoMultiplexingTissue-targeted Medicinesmanifold.bio
HQBoston, US
Team Size59
Open Jobs4
Total Funding$46M
Latest Fundraise8 months ago
Join the Team
Project Team Lead
On-SiteBoston, MA, US
On-Site • Boston, MA, US
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Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach.
Our drug discovery engine is differentiated by massively parallel screening
in vivo
from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.
Position
Manifold Bio is seeking an experienced drug discovery and development Project Team Leader (PTL) to lead cross-functional scientific teams to progress novel tissue-targeted therapeutic programs from early discovery to early clinical evaluation. The PTL will use their knowledge and experience of drug development, in combination with strategic guidance from company leaders, to define the integrated drug discovery and development strategies for 1-2 tissue-targeted therapeutic programs.
Responsibilities
Provides strategic and scientific leadership for cross-functional project teams focused on the development of tissue-targeted therapeutic molecules as they transition from early discovery (lead identification) into early clinical development.
Position Requirements
A PhD degree in life sciences or a scientific discipline related to drug development; MD, PharmD or MS with strong scientific and drug development background also considered
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
Develops clear work plan that maps out timing and resourcing requires to execute on critical path activities to progress novel lead tissue-targeted therapies from lead ID through early clinical testing, including candidate nomination, nonclinical PK and safety evaluation, CMC activities, regulatory submissions, and early clinical testing.
Maintains team focus on efficient execution IND-enabling workplans. Works with project managers to track execution of critical path activities relative to target timelines and budget.
Updates strategy based on emerging scientific data, changes in competitive landscape, and company strategic priorities; supports timely and clear project team decision-making that aligns with that strategy.
Facilitates identification and resolution of issues/gaps; risks and risk-mitigation strategies . Prioritizes timely, resource-efficient solutions that are aligned with company priorities.
Ensures cross-functional project team decisions are made in a timely manner and are aligned with company strategic priorities and latest scientific data.
Advocates for the program with internal and external stakeholders; supports two-way communication between senior leadership and project team members. Ensures the opinions and perspectives of internal and external partners and stakeholders are heard and understood.
Fosters a team culture of rigor, grit, accountability, and continuous improvement.
At least 7 years of biotech/pharmaceutical industry experience in drug development, spanning from discovery through initiation of first-in-human clinical studies
Experience in discovery and development of biologic and / or oligonucleotide therapies, with a focus on neuroscience, motor, or cardiometabolic therapeutic areas preferred
Excellent knowledge of drug development processes and deliverables at each stage of the pipeline
Successful track record of leading projects/program teams in a cross-functional team environment from early discovery through IND-enabling activities and ideally through early clinical development
Experience successfully leading projects with participation by external collaborators
Experience in oversight and successful integration of CROs, CDMOs, contractors and consultants
Excellent leadership skills with exceptional decision-making and analytical skills
Outstanding written and oral communication skills, with proven ability to build and maintain positive, collaborative working relationships
Excellent time management skills; comfortable driving toward on-time execution of deliverables in context of uncertain drug-development environmen
