Requirements What will you be doing?

• Design, execute, and analyze computational chemistry studies using a wide range of ligand-based, structure-based, and physics-based modeling techniques.
• Partner closely with medicinal chemists and biologists to develop and refine structure–activity relationships (SAR), optimize molecular properties, and guide design hypotheses.
• Contribute to project strategy and decision-making across all discovery stages, including target assessment, hit identification, lead optimization, and development candidate nomination.
• Champion innovative computational tools and workflows, identify and implement emerging technologies that enhance Frontier’s CADD capabilities – specifically with an eye to the applicability to the covalent domain.
• Work closely and partner with the AI team to develop and integrate novel AI applications into daily drug design workflows
• Communicate scientific results, design rationales, and strategic insights to multidisciplinary teams and senior leadership.

What are we looking for?

• Ph.D. in Computational/Theoretical Chemistry, Biophysics, or a related discipline with 5+ years of relevant industry experience in drug discovery (biotech or pharma).
• Demonstrated expertise in applying computational chemistry to small molecule design and optimization.
• Strong experience with leading computational chemistry tools, CCG tools including MOE is highly preferred
• Basic knowledge of scripting and programming with Python preferred
• Experience with quantum mechanics (QM) is highly preferred
• Proven track record of scientific impact, as evidenced by publications, patents, and successful project contributions.
• Solid understanding of medicinal chemistry principles, SAR analysis, and ADMET optimization.
• Excellent communication, presentation, and cross-functional collaboration skills.
• Ability to operate independently and as a scientific leader in a fast-paced, startup environment.
• Legally authorized to work in the U.S.

Benefits

• Health Care Plan (Medical, Dental & Vision)
• Retirement Plan (401k, IRA)
• Life Insurance (Basic, Voluntary & AD&D)
• Paid Time Off (Vacation, Sick & Public Holidays)
• Family Leave (Maternity, Paternity)
• Short Term & Long Term Disability
• Training & Development
• Free Food & Snacks
• Wellness Resources
• Stock Option Plan

At Frontier, we strive to build a diverse and equitable workplace. The salary range for this role is $175,000 - $231,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits. This compensation and benefits information is based on Frontier's knowledge as of the date of publication, and may be modified in the future.