Arc Institute

Arc Institute is a nonprofit biomedical research organization headquartered in Palo Alto, California, collaborating with Stanford University, UCSF, and UC Berkeley. It operates on a unique model providing fully funded, no-strings-attached multi-year support to scientists to pursue curiosity-driven research in complex diseases such as cancer, neurodegeneration, and immune dysfunction. The Institute invests heavily in developing experimental and computational technologies through dedicated Technology Centers focused on machine learning, genome engineering, cellular and animal disease models, and multi-omics. Arc aims to accelerate scientific progress and translate discoveries into patient impact by fostering interdisciplinary collaboration and long-term research agendas. It plans to scale to approximately 250 scientific personnel within three years, emphasizing innovative organizational models and translational infrastructure to optimize life sciences impact.

Biomedical ResearchCollaborative ResearchCuriosity-DrivenGenome EngineeringMulti-OmicsNonprofitTechnology DevelopmentTranslational Sciencearcinstitute.org

Arc Institute

Biomedical ResearchCollaborative ResearchCuriosity-DrivenGenome EngineeringMulti-OmicsNonprofitTechnology DevelopmentTranslational Sciencearcinstitute.org

HQPalo Alto, US

Team Size264

Open Jobs49

Total Funding-

Latest FundraiseUnknown

Join the Team

Postdoctoral Researcher, Bridge Editing Technology, Hsu Lab

On-SitePalo Alto, CA, US

On-Site • Palo Alto, CA, US

About Arc Institute

The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

Teeming tracks opportunities at over 24,000 AI startups, then works with you to find (and land) the one you'll love.

Data Scientist

InternshipNovi Sad, RS

Internship • Novi Sad, RS

DevOps Engineer

InternshipCambridge, GB

Internship • Cambridge, GB

Frontend Developer

InternshipNiš, RS

Internship • Niš, RS

Machine Learning Engineer

Part-timeNiš, RS

Part-time • Niš, RS

DevOps Engineer

Full-timeManchester, GB

Full-time • Manchester, GB

Backend Developer

InternshipAmsterdam, NL

Internship • Amsterdam, NL

TL;DR

Company Overview

Funding Track Record

Founders

What we do

Arc Institute

Biomedical ResearchCollaborative ResearchCuriosity-DrivenGenome EngineeringMulti-OmicsNonprofitTechnology DevelopmentTranslational Sciencearcinstitute.org

Arc Institute

Biomedical ResearchCollaborative ResearchCuriosity-DrivenGenome EngineeringMulti-OmicsNonprofitTechnology DevelopmentTranslational Sciencearcinstitute.org

HQPalo Alto, US

Team Size264

Open Jobs49

Total Funding-

Latest FundraiseUnknown

Join the Team

Postdoctoral Researcher, Bridge Editing Technology, Hsu Lab

On-SitePalo Alto, CA, US

On-Site • Palo Alto, CA, US

About Arc Institute

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

Teeming tracks opportunities at over 24,000 AI startups, then works with you to find (and land) the one you'll love.

Data Scientist

InternshipNovi Sad, RS

Internship • Novi Sad, RS

DevOps Engineer

InternshipCambridge, GB

Internship • Cambridge, GB

Frontend Developer

InternshipNiš, RS

Internship • Niš, RS

Machine Learning Engineer

Part-timeNiš, RS

Part-time • Niš, RS

DevOps Engineer

Full-timeManchester, GB

Full-time • Manchester, GB

Backend Developer

InternshipAmsterdam, NL

Internship • Amsterdam, NL

Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.

Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.

Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.

Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc has scaled to over 350 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.

About the position

The Hsu Lab is seeking applications for a Postdoctoral Researcher at the Arc Institute in Palo Alto, CA, focusing on the development and applications of novel genome engineering technologies. We recently discovered and developed Bridge Recombinases, which are naturally occurring RNA-guided DNA recombinases that can programmably insert, excise, and invert DNA (Nature, 2024 and Science, 2025). The candidate will continue to advance the efficiency and specificity of these systems through molecular engineering and technology development, in collaboration with biochemists, structural biologists and computational scientists in the lab, with the ultimate goal of enabling therapeutic applications in human cells and aiding genome design.

You are driven by science. The world of science is filled with so many unanswered questions and the opportunity to address these questions brings you purpose.
You are a collaborator. You love working with people of different backgrounds and brainstorming ideas on how these questions can be addressed.
You are intellectually independent and self-motivated to push the boundaries of novel technologies.
You are an optimizer. In research, there’s always a race against the clock. You care deeply about making every step of the way as close to perfect as possible but also as quick and efficient as possible.
You build tools. As much as you love answering specific scientific questions, you also love creating technology and platforms that are scalable and useful in many different scientific application areas.

In this position you will

Be the hands-on lead of one or multiple scientific projects in molecular technology development including planning, execution, analysis of experiments.
Collaborate closely with the PIs on planning and executing scientific research projects.
Keep up-to-date on advances in the field by reading the literature and attending key conferences.
Mentor Research Associates and/or graduate students
Develop and provide training to lab personnel as needed, develop standardized protocols for the labs.
Publish preprints and journal articles; present findings at conferences

Job Requirements

PhD in a relevant life sciences or engineering field
Experience with different molecular biology assays and techniques, including high-throughput cloning
Mammalian cell culture experience
Experience with NGS and flow cytometry techniques and data analysis
Prior experience in developing genome engineering technologies (CRISPR, recombinases, transposases, etc.) preferred
Strong written and verbal communication skills
Experience and enthusiasm for mentoring research trainees, including graduate students and RAs
The successful candidate will be an ambitious self-starter, an innovative and meticulous researcher, and enjoy working in a collaborative and fast-paced team environment

How to apply Please submit:

CV
Brief cover letter describing your research interests and why the Hsu Lab is a fit. Please be sure to include contact information for 3+ references.

The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.