Arc Institute is a nonprofit biomedical research organization headquartered in Palo Alto, California, collaborating with Stanford University, UCSF, and UC Berkeley. It operates on a unique model providing fully funded, no-strings-attached multi-year support to scientists to pursue curiosity-driven research in complex diseases such as cancer, neurodegeneration, and immune dysfunction. The Institute invests heavily in developing experimental and computational technologies through dedicated Technology Centers focused on machine learning, genome engineering, cellular and animal disease models, and multi-omics. Arc aims to accelerate scientific progress and translate discoveries into patient impact by fostering interdisciplinary collaboration and long-term research agendas. It plans to scale to approximately 250 scientific personnel within three years, emphasizing innovative organizational models and translational infrastructure to optimize life sciences impact.
Arc Institute is a nonprofit biomedical research organization headquartered in Palo Alto, California, collaborating with Stanford University, UCSF, and UC Berkeley. It operates on a unique model providing fully funded, no-strings-attached multi-year support to scientists to pursue curiosity-driven research in complex diseases such as cancer, neurodegeneration, and immune dysfunction. The Institute invests heavily in developing experimental and computational technologies through dedicated Technology Centers focused on machine learning, genome engineering, cellular and animal disease models, and multi-omics. Arc aims to accelerate scientific progress and translate discoveries into patient impact by fostering interdisciplinary collaboration and long-term research agendas. It plans to scale to approximately 250 scientific personnel within three years, emphasizing innovative organizational models and translational infrastructure to optimize life sciences impact.
Machine Learning Research Lead, Alzheimer's Disease Initiative
On-SitePalo Alto, CA, US
On-Site • Palo Alto, CA, US
About Arc Institute
The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.
While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:
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Funding:
Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.
Technology:
Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.
Support:
Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
Culture:
We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.
Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.
About the Position
We are searching for an exceptional scientific leader to establish a new team within Arc Institute’s Computational Technology Center, serving as Machine Learning Research Lead, for our Alzheimer's Disease Initiative (ADI).
This ambitious initiative spans Arc's Technology Centers and Core Investigator Laboratories and focuses on high-throughput interrogation of neurodegeneration and Alzheimer's disease mechanisms using advanced gene editing and functional genomics approaches. As the Machine Learning Research Lead, ADI, you will spearhead development of sophisticated machine learning foundation models to capture cell states and infer gene regulatory networks and causal relationships to predict therapeutic interventions.
This position offers the rare opportunity to build and lead a world-class team while making direct contributions to understanding and potentially treating Alzheimer's disease through state-of-the-art computational biology and machine learning approaches.
About You
You are passionate about machine learning and computational biology
, with expertise in applying cutting edge ML approaches to biological systems
You excel at developing interpretable machine learning approaches
, such as variational inference and causal modeling methods
You are excited about building and leading a technical team while remaining hands-on
with foundation model development and implementation.
You thrive in collaborative, multidisciplinary environments
and enjoy working with both computational scientists and wet lab biologists
You are a continuous learner who stays current with the latest developments,
in both machine learning and neuroscience
In This Position, You Will
Attract, build and lead a team of exceptional machine learning research scientists dedicated to developing foundation models for cellular systems in Alzheimer's disease
Develop and execute on a roadmap of interpretable machine learning approaches to understand disease mechanisms, with emphasis on variational inference, causal modeling, as well as modern transformer- and diffusion-based architectures
Work closely with experimentalists on brain organoid/spheroid cellular models as well as
in vivo
models, working with scRNA-seq, Perturb-seq and other datasets to unravel causal gene pathways relevant to Alzheimer’s disease
Develop predictive modeling approaches to identify how perturbations can move cell states from high risk Alzheimer’s profiles back to healthy / low risk states
Collaborate closely with experimental biologists to ensure ML models are grounded in disease biology and can feedback into future experimental strategies
Foster collaborations with external partners in the computational biology and neuroscience communities
Publish high-impact research through preprints, journal publications, open source code, and presentations at leading conferences
Required Qualifications
PhD in Computational Biology, Bioinformatics, Machine Learning, Computer Science, or related quantitative field
7+ years of relevant experience with a minimum of 3 years of people management experience
Strong research background with experience in academic settings (university, research institute) and/or biotech/pharmaceutical industry with a focus on scientific innovation
Proven expertise in machine learning applications to biological datasets, with specific experience in single-cell profiling data and foundation model development
Deep experience with interpretable machine learning approaches for biological systems (e.g. variational inference methods).
Advanced technical skills in machine learning frameworks, particularly PyTorch, and ideally experience with model training at scale
Publications in top-tier journals in computational biology and machine learning
Excellent communication skills with ability to present complex machine learning concepts to both computational and biological audiences
Proven ability to remain technically hands-on while providing effective team leadership, mentorship, and management
Background in neurodegeneration research including familiarity with Alzheimer's disease datasets, pathways, networks, disease mechanisms, and eQTL analysis is a plus
The base salary range for this position is $338,500 to $400,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.
