TandemAI is advancing the field of drug discovery by combining AI-driven, high-performance computing with scalable, in-house wet lab operations. With a mission to streamline the drug discovery process, the company offers a comprehensive, integrated platform built to accelerate results and optimize costs. TandemAI is dedicated to delivering breakthrough solutions to its partners and the global scientific community.
ABOUT THE ROLE
The Free Energy Investigator/Sr. Investigator/Principal will participate in the research and development of state-of-the-art molecular dynamics-based free energy methods, which are at the heart of TandemAI’s platform for accelerating drug discovery.
Responsibilities:
- Research and develop methods in molecular simulations and free energy calculations to improve the precision, accuracy, and efficiency of protein-ligand binding free energy predictions
- Expand the applicability of free energy methods to different parts of the drug discovery process with novel approaches
- Develop robust and turnkey free energy workflows with zero to minimal user intervention
- Work closely with multidisciplinary teams of computational and medicinal chemists, data and software engineers, biophysicists, and biologists to integrate free energy calculations into our discovery platform and quantitatively keep track of their effectiveness
Qualifications:
- PhD in Chemistry, Physics, or related discipline with 5+ years relevant industrial experience post-PhD (or MS in one of these fields with 7+ years of related experience)
- Extensive hands-on experience in molecular dynamics simulations, free energy calculations, and enhanced sampling methods
- Extensive programming experience (C/C++ and Python preferred) and familiarity with Linux and high-performance computing resources
- Strong analytical and problem solving skills
- Excellent written and oral communication skills, including an ability to explain complex ideas to non-specialists
- Experience with computer-aided drug design, chemo informatics, drug discovery, and machine learning
- Highly motivated to develop computational methods for discovering better medicines
Perks and Benefits:
- Bonus
- Stock Options
- Comprehensive healthcare benefits
- 401(k) retirement plan
- Flexible Spending Accounts (FSAs)
- Commuter benefits
- Hybrid work schedule
Salary Range:
$100,000 - $170,000
