
4Dcell is a biotechnology company specializing in advanced 2D and 3D in vitro cell culture technologies designed to accelerate drug discovery and reduce animal testing. Their proprietary platforms, including SmartHeart and SmartContractility, enable precise modeling of cardiac and other tissues with high reproducibility and ease of use. The company integrates material sciences, physics, and AI-driven imaging analysis to deliver physiologically relevant models for drug efficacy, cardiotoxicity, and fundamental research. Their products support scalable, ethical, and predictive preclinical studies, positioning 4Dcell as a leader in organoid and tissue engineering solutions for pharmaceutical and biomedical research markets.

4Dcell is a biotechnology company specializing in advanced 2D and 3D in vitro cell culture technologies designed to accelerate drug discovery and reduce animal testing. Their proprietary platforms, including SmartHeart and SmartContractility, enable precise modeling of cardiac and other tissues with high reproducibility and ease of use. The company integrates material sciences, physics, and AI-driven imaging analysis to deliver physiologically relevant models for drug efficacy, cardiotoxicity, and fundamental research. Their products support scalable, ethical, and predictive preclinical studies, positioning 4Dcell as a leader in organoid and tissue engineering solutions for pharmaceutical and biomedical research markets.
R&D project manager assistant - Internship
Unlock the Future of Drug Discovery.
Join 4Dcell and become part of a pioneering French biotech on a mission to transform drug discovery and toxicology. We’re engineers and biologists united by a single goal: to replace animal testing with intelligent, in vitro “organ-in-a-well” models that deliver unprecedented predictive power to drive tomorrow’s therapies.
4Dcell has developed two flagship solutions: the SmartHeart™ Platform, which recreates human ventricular tissue in a standard 96-well plate, and the first-in-class SmartSphero™ Technology, enabling the generation of a wide range of organoids.
You’ll collaborate with leading biophysicists, engineers, and biologists to tackle the toughest health challenges, from heart failure and immuno-oncology to pancreas and renal diseases. We combine ambition with a supportive, curiosity-driven culture.
Why intern with us?
• Freedom and responsibility to structure and lead your own projects
• Hands-on exposure to game-changing technologies
• Apply marketing skills on a new, growing, exciting and revolutionary market
• A team that values collaboration, growth, and fun
• Membership in a high-energy, fast-growing team developing truly game-changing, high-tech products
• The opportunity to navigate both a commercial start-up environment and an R&D scientific setting
• Close collaboration with experts in technology, marketing, sales, application science and operations
• Step into a role where your work accelerates drug discovery, improves patient outcomes, and builds amore ethical pharmaceutical future.
Context
Within our R&D team, you will work hands-on with experimental protocols to characterize cardiac pathologies and cardiac cell line maturation.
Main Responsibilities
Executing Design of Experiments (DoE)
• Prepare culture media and reagent dilutions
• Seed cells at defined densities according to the DoE matrix
• Record all steps and observations in the lab notebook (LIMS/Excel)Data
Processing & Analysis
• Import raw metrics (viability, marker expression, contractility)
• Create summary tables and plots to compare conditions
• Draft concise experimental summaries with actionable conclusions
3D Cell Culture
• Set up cardiac organoid (SmartHeart)
• Conduct immunofluorescent staining and confocal imaging
• qPCR analysis
Deliverables
• Complete experimental records (DoE details, raw results, observations)
• Analyzed datasets with clear graphical outputs
• Updated operational protocols
• Brief reports for each experimental campaign
Environment & Tools
• Equipment: CO₂ incubators, laminar-flow hoods, confocal microscope
• Software: LIMS/Excel, GraphPad Prism, R or basic Python notebooks
• Techniques: DoE, 2D & 3D cell culture, immunofluorescence
Candidate Profile
• Master’s student in Biology, Biotechnology or Biomedical Engineering
• Hands-on experience with cell culture (2D and/or 3D)
• Comfortable with data entry and analysis
• Experienced in Molecular Biology
• Organized, experimentally rigorous and proactive
• Good technical English
Duration & Terms
• 6-month internship, starting January or February 2026
• Based in Montreuil (Paris), France
Legal internship stipend 650€ + partial transport reimbursement