In vitro Biology Scientist, ADME/IVB Profiling team

Job description

About Topia Life Sciences ltd

Topia Life Sciences ltd, headquartered in London, is an innovation-driven TechBio company established in 2021. We specialise in accelerating Drug Discovery through advanced AI technologies, scientific expertise and strategic collaborations. At the heart of our operations is SMAG (Smart Molecule Generation), a proprietary AI platform that integrates data analytics, molecular simulation and AI-driven modelling to streamline drug design, repurposing, toxicity prediction and optimisation of therapeutic candidates.

With a growing pipeline of small molecule programs and services, our mission is to transform Healthcare by reducing Discovery timelines and improving Therapeutic solutions to patients . We foster a collaborative culture and actively pursue strategic alliances to amplify our global impact in Biotech and Pharma.

About the role

We have an opportunity for a full-time, lab-based in vitro Biology scientist as part of the growth of our compound profiling team. The ideal candidate will have a track record in developing biochemical/biophysical assays in 96- and 384-well formats using the latest technologies, and experience in profiling compounds for potency, affinity and mechanism of action.

As a key member of the Topia profiling team, you will support the efficient execution of our programs with high-quality decision-making data. You will be expected to maintain the highest levels of compliance in safety and record keeping.

This role is part of Topia’s capability build to deliver on our pipeline of internal and partnered programs, while having an impact on expanding Topia Tech Infrastructure.

This Ahmedabad-based position reports directly to ADME/IVB Profiling Senior Manager.

Key Responsibilities

Experimental Design & Execution

• Develop in vitro enzymatic/biophysical assays, including functional and binding methods using fluorescence and luminescence technologies.
• Produce robust, reproducible in vitro data in support of Discovery programs.
• Design more complex assays to elucidate the mechanism of compound action, including kinetic determinations, and reversibility studies.

Data Analysis & Interpretation

• Perform data processing, curve fitting and statistical analysis. Generate and track quality metrics to ensure quality.
• Provide interpretation of in vitro results to cross-functional teams.

Collaboration & Reporting

• Coordinate effectively with cross-functional teams (e.g., Computational & synthetic chemistry, biology, clinical) to ensure program timelines are met. Act with a sense of urgency and in accordance with prioritisation established by Topia Leadership.
• Prepare reports and presentations for internal meetings and stakeholders. Ensure contemporaneous experimental record keeping.
• Promote our culture of collaboration and inclusion as an ambassador of our Topia Scientific Excellence program.

Qualifications & Skills

• PhD or Master’s in Pharmacology, Pharmaceutical Sciences, Biochemistry, or related field.
• 3–5 years for entry-level; 7+ years for senior/principal scientist roles.
• Working knowledge of in vitro drug discovery concepts and processes.
• Expertise in the development/validation, optimization, and implementation of assays for DMTA cycles and mechanism of action studies.
• Proficiency with a range of contemporary biochemical techniques (eg., luminescence, TR-FRET, HTRF, FP. SPR is a plus)
• Familiarity with pharmacological principles, data analysis, related software and statistical tools.

What we offer

• Competitive salary, including benefits.
• Flexible working hours.
• Opportunity to contribute to groundbreaking AI innovations in Healthcare and strategic influence over the expansion of an AI-native TechBio organisation spearheading Precision Design of new drugs
• Collaborative culture with access to a global network of experts.
• Professional development and involvement in high impact projects.