About Ensocell
Ensocell is a UK biotechnology company advancing next-gen precision biologics for autoimmune and fibrotic diseases. Our therapeutic design is informed by ENSO AI, a platform that identifies molecular targets and predicts disease biology with a new level of precision. We combine deep immunology expertise with modern data science to build programmes with a clear path from discovery through early clinical development. This role is a chance to help shape our translational strategy and directly influence key programme decisions in a fast-moving biotech environment.
What you will do
You’ll lead and deliver translational strategy across multiple programmes, working closely with Discovery Biology, Data Science and (as we progress) Clinical and Regulatory colleagues. Day-to-day, you will:
- Define biomarker and target engagement plans from discovery through early clinical development (mechanism, target engagement, proof-of-biology, stratification).
- Design fit-for-purpose translational studies using human biospecimens and relevant disease biology to enable selection of the right patient populations.
- Develop and commission assays (e.g., immunoassays, cellular assays, flow cytometry; omics-enabled approaches where appropriate).
- Partner with PK modelers to use preclinical PK/PD to predict human doses and therapeutic window assumptions.
- Input into the design of clinical studies that can demonstrate target engagement and pharmacodynamic effects in the right patient and with early efficacy signals.
- Contribute to regulatory filings including drafting translational sections and study reports for IND/CTA packages.
- Work effectively with external partners (academia, clinical collaborators, CROs, specialist laboratories) to deliver assays and analyses.
- Communicate results clearly to technical and non-technical stakeholders; contribute to abstracts, posters, and publications when aligned to company strategy.
- Help build translational capability across the company (ways of working, scientific rigour, mentoring/support as needed).
What we are looking for
Essential
- PhD, MD (or equivalent experience) in Immunology or a closely related life science discipline.
- Significant experience (typically 6+ years) in translational research using primary/complex cell assays, supporting antibody drug discovery and/or early clinical development, ideally in autoimmune disease areas (e.g., rheumatology, respiratory, gastroenterology).
- A proven track record developing and executing biomarker strategies (study design, assay planning, data interpretation, and decision-making).
- Experience drafting IND/CTA packages and interacting with regulatory authorities.
- Experience with external collaboration management (academia, clinical partners, CROs).
- Strong cross-functional working style and the ability to prioritise across parallel programmes.
Desirable
- Experience operating in a matrix environment common to high-growth biotech.
- Experience with project management tools.
- Familiarity with high-content datasets and computational/statistical approaches (including AI/ML applications in translational medicine).
Benefits (what we offer)
We offer a competitive package, which typically includes:
- Competitive salary and equity participation
- Enhanced employer pension contribution
- Generous annual leave plus UK bank holidays
- Private Medical, Income Protection, Critical Illness, Employee Assistance Plan
- Training and development support
- A collaborative, science-led culture at Babraham Research Campus
