Valthos Inc. Valthos builds next-generation biodefense. Of all AI applications, biotechnology has the highest upside and most catastrophic downside. The world is approaching near-universal access to powerful, dual-use biotechnologies capable of eliminating disease or creating it.

At Valthos, our mission to make sure the technologies to characterize biological threats and update our medical countermeasures advances faster than the threats we face. Our team of computational biologists and software engineers develop, evaluate, and deploy frontier AI methods in software to support critical workflows in government and pharmaceutical development. The AI systems we develop today will accelerate our ability to respond to threats and lay the groundwork for the adaptive, precision therapeutics of tomorrow.

Our founding team comes from Palantir, DeepMind, the Broad Institute, and the Arc Institute, and we are supported by world class investors from OpenAI, Lux Capital, and Founders Fund.

The Role

Valthos is building a platform to support a wide range of stakeholders in government and pharma, with a specific focus on strengthening biodefense programs in the Department of War (DoW).

We are looking for a Head of Operations who can own the entire operational backbone of the company: HR, Finance, Legal & Compliance, and strategic support for GTM. This is one of the most central roles in the company, you will partner directly with the founders to ensure the company runs with excellence and that our team can focus entirely on building.

We are looking for a systems-oriented, detail-obsessed operator who can build and run all internal operations with a founder mindset. You will design processes, own execution, and be the connective tissue across the company. This is a role for someone who loves high-velocity environments, is comfortable with complexity, and holds an extremely high standard for accuracy, organization, and follow-through.

You will manage and eventually build the broader Operations function as the company scales. This role sits directly beneath the founders and is a strong future-COO track.

Responsibilities

• Drive financial operations: oversee fundraising workflows, budgeting, forecasting, monthly close, cash management, and spend controls.
• Lead legal & compliance: manage lawyers, contracts, equity/cap table hygiene, state registrations, insurance, and regulatory documentation.
• Support growth & strategic initiatives: track and organize customer-facing materials, coordinate PR/press, and run events/dinners related to hiring and GTM.
• Run the Talent engine: own recruiting operations, candidate experience, onboarding, payroll, benefits, and HR compliance.
• Own day-to-day operations: ensure smooth office operations across locations, manage founder scheduling, vendors, equipment, and internal systems.