Head of Clinical Development & Strategy | Nosis Bio · Teeming.ai
Nosis Bio
Nosis Biosciences is a biotechnology company focused on revolutionizing RNA medicines by addressing the critical challenge of cell-specific delivery. Their proprietary platform, Connexa, leverages…
Nosis Biosciences is a biotechnology company focused on revolutionizing RNA medicines by addressing the critical challenge of cell-specific delivery. Their proprietary platform, Connexa, leverages…
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About Nosis Bio
Nosis Bio is an AI-enabled biotechnology company pioneering the future of receptor-targeted RNA therapeutics. By combining an AI-powered drug delivery and design platform with deep learning, we are unlocking the next generation of gene silencing medicines. Backed by world class institutional capital, large pharma collaborations, and multiple internal programs advancing toward the clinic, we are rapidly scaling our pipeline and our team.
The Role
We are seeking a visionary and highly strategic MD/PhD to serve as our Head of Clinical Strategy & Development. Reporting directly to the CEO, you will be the clinical anchor of our executive team. Your primary focus will be driving the clinical strategy for our internal pipeline-defining Target Product Profiles (TPPs), establishing rigorous success criteria, and ensuring we are building the most important, medically necessary products possible.
Alongside your internal focus, you will serve as the primary clinical architect for our external pharma collaborations, ensuring our partners maximize the therapeutic utility of our delivery platform. You will partner closely with our CTO and the technical leadership team (Machine Learning, Chemistry, and Translation) to bridge the gap between our cutting-edge drug design platform and human clinical reality.
Key Responsibilities
Qualifications
Education:
MD or PhD required. MD/PHD ideal.
Internal Pipeline & TPP Development:
Lead the definition and continuous refinement of Target Product Profiles (TPPs) for all preclinical assets. Ensure alignment between our AI/discovery capabilities and commercial/clinical viability.
Establish Success Criteria:
Define clear, stage-gated clinical and pre-clinical success criteria for every program in the Nosis Bio pipeline. Work seamlessly with the Director of Translation, Director of Chemistry, and ML team to ensure these milestones are met.
Shape Pharma Collaborations:
Act as the lead clinical representative with our pharmaceutical partners. Co-develop and refine TPPs within these collaborations, deeply understanding partner objectives to guide them on the most clinically viable ways to deploy our targeted delivery technology.
KOL & Advisory Board Leadership:
Identify, build, and maintain deep relationships with Key Opinion Leaders (KOLs) and clinical experts across our target indications to validate and refine our internal product strategy.
External Representation:
Serve as clinical face of Nosis Bio. Represent our clinical strategy to external stakeholders, including institutional investors during upcoming fundraising cycles, partners, regulatory agencies, and the broader medical community.
Cross-Functional Integration:
Partner tightly with the CTO and technical platform teams to ensure that our AI delivery and drug design outputs are constantly informed by real-world clinical constraints and endpoints.
Experience:
5+ years of strategic clinical development experience within the biotechnology or pharmaceutical industry, ideally with exposure to early-stage, fast-paced environments.
Domain Expertise:
Strong foundational understanding of targeted therapeutics; specific experience with RNAi/siRNA, or advanced drug delivery modalities is a significant plus. Significant experience across multiple, distinct therapeutic areas including fibrosis, immunology, neurology, and/or cardiometabolic disease.
Strategic Chops:
Proven track record of developing TPPs, shaping early-stage pipeline strategy, and defining clear go/no-go criteria for novel therapeutics.
Collaboration Experience:
Demonstrated ability to work alongside external clinical teams in pharma collaborations, helping to shape joint clinical strategy and maximize platform value.
Communication & Clout:
Exceptional ability to communicate complex clinical and scientific concepts to diverse audiences, from ML engineers to top-tier investors and pharma executives. A recognized presence capable of commanding respect from KOLs.
