About Nosis Bio Nosis Bio is an early-stage biotechnology company pioneering the future of receptor-targeted RNA therapeutics. By combining an AI-powered drug delivery and design platform with deep learning, we are unlocking the next generation of siRNA medicines. With multiple programs heading into the clinic internally and through collaborations, we are rapidly scaling our pipeline and our team.

The Role We are seeking a visionary and highly strategic MD/PhD to serve as our Head of Clinical Strategy & Development. Reporting directly to the CEO, you will be the clinical anchor of our executive team. Your primary focus will be driving the clinical strategy for our internal pipeline-defining Target Product Profiles (TPPs), establishing rigorous success criteria, and ensuring we are building the most important, medically necessary products possible.

Alongside your internal focus, you will serve as the primary clinical architect for our external pharma collaborations, ensuring our partners maximize the therapeutic utility of our delivery platform. You will partner closely with our CTO and the technical leadership team (Machine Learning, Chemistry, and Translation) to bridge the gap between our cutting-edge drug design platform and human clinical reality.

Key Responsibilities

• Internal Pipeline & TPP Development (Primary Focus): Lead the definition and continuous refinement of Target Product Profiles (TPPs) for all early-stage assets. Ensure alignment between our AI/discovery capabilities and commercial/clinical viability.
• Establish Success Criteria: Define clear, stage-gated clinical and pre-clinical success criteria for every program in the Nosis Bio pipeline. Work seamlessly with the Director of Translation, Director of Chemistry, and ML team to ensure these milestones are met.

Qualifications

• Education: MD or PhD required. MD/PHD ideal.
• Experience: 5+ years of strategic clinical development experience within the biotechnology or pharmaceutical industry, ideally with exposure to early-stage, fast-paced environments.
• Domain Expertise: Strong foundational understanding of targeted therapeutics; specific experience with RNAi/siRNA, or advanced drug delivery modalities is a significant plus. Significant experience across multiple, distinct therapeutic areas including fibrosis, immunology, neurology, and/or cardiometabolic disease.
• Strategic Chops: Proven track record of developing TPPs, shaping early-stage pipeline strategy, and defining clear go/no-go criteria for novel therapeutics.
• Collaboration Experience: Demonstrated ability to work alongside external clinical teams in pharma collaborations, helping to shape joint clinical strategy and maximize platform value.