About OrganoBit

OrganoBit BioIntelligence is pioneering Organoid Design Automation by integrating AI-driven organoid informatics, in silico modeling, and advanced biological world models to transform precision medicine and drug development. We focus on discovering, designing, and optimizing organoid culture protocols to accelerate preclinical and early clinical testing, with a vision that organoids will power a substantial share of this market by 2035. Through automation and intelligent systems, we aim to dramatically reduce organoid manufacturing costs and make human-relevant preclinical models broadly accessible to the pharmaceutical industry.

Role Overview

We are seeking a Director of Organoid Culture Laboratory to lead our High-Throughput Organoid Protocol Validation program in Singapore. In this role, you will be fully responsible for designing the end-to-end validation workflow, prioritizing which organoid protocols to validate, and establishing the core architecture of our validation and screening system.

This is a hands-on, strategic role at an early-stage startup. You will build robust, automation-ready organoid workflows, generate high-quality assay data at scale, and tightly integrate the lab with our AI and data platforms.

Key Responsibilities

• Own the design and implementation of a high-throughput organoid protocol validation workflow, from plate design to readout and analysis.
• Prioritize and select organoid culture protocols (e.g., PDO and stem cell–derived systems) for validation based on technical feasibility, robustness, and market impact.
• Develop, optimize, and standardize organoid culture, passaging, and assay protocols that are compatible with automation (e.g., 96/384-well formats, liquid handling systems).

Qualifications

• PhD (preferred) or Master’s in Biotechnology, Cell Biology, Stem Cell Biology, Bioengineering, or a related field.
• Strong hands-on experience with organoid culture, 3D cell systems, or advanced in vitro models, ideally including patient-derived organoids.
• Proven experience designing, optimizing, and troubleshooting complex biological protocols, preferably in a high-throughput or screening context.
• Proficiency in key laboratory techniques and principles from pathology, laboratory medicine, and microbiology, as applied to organoid systems.

Who You Are

You are a scientist–builder who wants to own the full validation pipeline—from plate map design and controls to data quality metrics and decision rules. You are excited to move beyond one-off experiments and instead architect scalable workflows that can run hundreds to thousands of organoid assays reliably. You thrive in an early-stage, high-ownership environment and are motivated by the impact of making organoid-based testing practical at scale.

What We Offer

• A foundational leadership role in a deep tech biotech startup at the intersection of organoids, automation, and AI.
• The mandate to design and own the core high-throughput validation architecture from day one.
• Competitive compensation with meaningful equity.
• Close collaboration with a multidisciplinary founding team across biology, AI, and engineering.
• Hybrid work setup based in Singapore.