Key Responsibilities

• Define and execute DMPK and PK/PD strategies for miniprotein based therapeutics from discovery through IND-enabling stages
• Design, oversee, and interpret in vitro/in vivo PK and PK/PD studies in relevant preclinical species
• Develop mechanistic and translational PK models, including considerations of target-mediated drug disposition
• Partner closely with Protein Design, Pharmacology, Toxicology, and Translational Biology to inform molecule design and optimization
• Guide bioanalytical strategy, including ligand-binding assays and immunogenicity considerations, working with CROs as needed
• Support first-in-human dose prediction and clinical PK strategy
• Contribute to regulatory documentation (e.g., IND/IMPD sections related to PK/PD)
• Serve as the DMPK representative on cross-functional project teams and scientific governance
• Help establish best practices and scalable processes appropriate for a growing biotech

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or a related discipline (or equivalent practical experience)
• Typically 8+ years of industry experience in DMPK, with strong exposure to biologics or protein therapeutics
• Solid understanding of PK/PD principles for proteins, including clearance mechanisms and biodistribution
• Experience supporting candidate progression and development decisions
• Demonstrated ability to work effectively in small, fast-moving, cross-functional teams

Preferred Experience

• Experience with miniproteins, peptides, or novel biologic modalities
• Familiarity with PK/PD and translational modelling
• Experience managing external CROs for DMPK and bioanalysis
• Exposure to IND-enabling or early clinical programs

What we offer

• Frontier technology: We’re building an AI-driven GPCR discovery engine, proven by the world’s first de novo designed agonists and powered by a breakthrough screening platform.
• Supportive and ambitious culture: thoughtful teammates, direct communication, and a bias toward action and learning.
• High trust, high ownership: minimal bureaucracy, wide scope, and meaningful responsibility from day one.
• BII home base: centrally located in Copenhagen, embedded in the BioInnovation Institute, with access to excellent shared infrastructure and community.
• Competitive compensation: salary and benefits including warrants, pension, lunch, and private health insurance.

Apply for the job

Do you want to join our team as our new Director of DMPK & Biodistribution? Then we'd love to hear from you! Apply here: https://skape-bio.homerun.co/director-of-dmpk-biodistribution/en