Skape Bio

Skape Bio is a biotechnology company revolutionizing GPCR drug discovery through AI-powered protein design and high-throughput screening technology. Their innovative platform integrates deep evolutionary insights with advanced methodologies to create novel modulators of integral membrane proteins, enabling the discovery of unique agonists and antagonists. By utilizing in-cell screening, they can evaluate thousands of designs in their natural context, accelerating the development of therapeutics for oncology, inflammation, metabolic disease, and neurology. Skape Bio, a spinout from a collaboration between the BioInnovation Institute and the University of Washington’s Institute for Protein Design, is positioned to lead in the biopharmaceutical space with its cutting-edge technology and partnerships with pharmaceutical companies.

AI-poweredDrug DiscoveryGPCRHigh-throughput ScreeningProtein DesignTherapeuticsskape.bio

Skape Bio

AI-poweredDrug DiscoveryGPCRHigh-throughput ScreeningProtein DesignTherapeuticsskape.bio

HQCopenhagen, DK

Team Size12

Open Jobs3

Total Funding-

Latest FundraiseUnknown

Join the Team

Director of Data Engineering

On-SiteCopenhagen, Capital Region of, DK

On-Site • Copenhagen, Capital Region of, DK

Teeming tracks opportunities at over 24,000 AI startups, then works with you to find (and land) the one you'll love.

Frontend Developer

InternshipJerusalem

Internship • Jerusalem

Data Scientist

Full-timeNew York, US

Full-time • New York, US

Machine Learning Engineer

Full-timeNiš, RS

Full-time • Niš, RS

Product Designer

Part-timeUtrecht, NL

Part-time • Utrecht, NL

DevOps Engineer

ContractCambridge, GB

Contract • Cambridge, GB

DevOps Engineer

ContractMunich, DE

Contract • Munich, DE

About Skape Bio

Skape Bio is an early-stage, venture-backed biotechnology company, co-founded by Nobel Laureate David Baker to develop de novo designed miniprotein therapeutics for GPCRs. Our platform integrates computational design, protein engineering, novel screening technology and translational science deliver breakthrough medicines where significant unmet medical needs remain and traditional modalities have failed to provide a solution.

We are building a highly collaborative team where passionate individuals thrive in a hands-on, high-impact environment. Our culture is open and supportive, emphasizing initiative, teamwork, rapid learning, and high standards.

Position overview

Skape Bio’s discovery engine rests on three pillars: de novo protein design with AI models, high-throughput screening, and translational biology. We are hiring a Director of Data Engineering to own the software, data, and compute foundations for protein design and experimental workflows.

You will architect, build, and refine the pipelines and infrastructure needed for large-scale protein design, and for converting experimental assay data into usable training sets and fine-tuned models. This is a high-ownership, hands-on role, with freedom to architect the stack and raise the bar on reliability, reproducibility, and speed.

Responsibilities

Own the platform end to end: Set the technical direction for Skape Bio’s data and compute stack, and drive the roadmap from first principles (speed, scale and reliability)
Protein design and ML infrastructure: Own the cloud infrastructure that supports innovative, efficient protein design workflows, including dataset curation, model training and evaluation, large-scale inference, and experiment tracking
Production data pipelines for high-throughput screening and translational biology: Architect, build, and refine pipelines for analysis of terabyte-scale image and sequence data, biological data and turn raw data into trusted, reproducible datasets for modelling and decision making
Deployment, reliability, and operational rigor: Operate the platform with production-level monitoring and clear ownership, continuously improve reliability and performance, and establish release practices that protect critical workflows

Required Qualifications

Education: BSc, MSc, or PhD in Computer Science, Software Engineering, Data Science, Bioinformatics, Computational Biology, or a related field (or equivalent practical experience)
Senior platform leadership: 5+ years owning production data/compute platforms end to end. Experience with managing engineers (hiring, mentoring, setting standards) is a plus
Strong software engineering in Python: You build complex, reliable systems with testing, type checking (e.g., mypy), and clear code review/documentation practices; comfortable running CI/CD and disciplined releases. Experience with bioinformatics is preferred
Cloud and infrastructure depth: Hands-on with GCP (incl. BigQuery), Terraform/IaC, containers and orchestration (e.g., Kubernetes/schedulers), and operating GPU/CPU fleets for high-throughput scientific workloads
Data and ML ops (deployment-first): Build versioned, reproducible pipelines with strong data modeling, provenance, and QC, and deploy/operate scalable model inference/serving (monitoring/alerting, incident response, safe rollouts/rollbacks, experiment tracking). Familiarity with PyTorch and nextflow/airflow is a plus

What we offer

Frontier technology: We’re building an AI-driven GPCR discovery engine, proven by the world’s first de novo designed agonists and powered by a breakthrough screening platform.
Supportive and ambitious culture: thoughtful teammates, direct communication, and a bias toward action and learning.
High trust, high ownership: minimal bureaucracy, wide scope, and meaningful responsibility from day one.
BII home base: centrally located in Copenhagen, embedded in the BioInnovation Institute, with access to excellent shared infrastructure and community.
Competitive compensation: salary and benefits including warrants, pension, lunch, and private health insurance.

Apply for the job

Do you want to join our team as our new Director of Data Engineering? Then we'd love to hear from you! Apply here: https://skape-bio.homerun.co/director-of-data-engineering/en