
Sethera Therapeutics develops next-generation peptide drugs using a proprietary enzymatic cross-linking technology to make highly stable polymacrocyclic peptides. Their pMCP Discovery Platform supports library creation, AI-powered data generation, and noncanonical building blocks, enabling partners in pharma and research institutions to discover and optimize peptide therapeutics. The core technology includes a cyclization enzyme that site-specifically installs thioether bonds, enabling up to six macrocycles per peptide. The platform integrates AI, mRNA display, phage display, and DNA-encoded libraries to explore diverse sequence-structure space and tailor architectures for challenging targets. Sethera seeks partnerships and licensing with pharmaceutical companies to bring novel therapies to market.

Sethera Therapeutics develops next-generation peptide drugs using a proprietary enzymatic cross-linking technology to make highly stable polymacrocyclic peptides. Their pMCP Discovery Platform supports library creation, AI-powered data generation, and noncanonical building blocks, enabling partners in pharma and research institutions to discover and optimize peptide therapeutics. The core technology includes a cyclization enzyme that site-specifically installs thioether bonds, enabling up to six macrocycles per peptide. The platform integrates AI, mRNA display, phage display, and DNA-encoded libraries to explore diverse sequence-structure space and tailor architectures for challenging targets. Sethera seeks partnerships and licensing with pharmaceutical companies to bring novel therapies to market.
Job Summary:
We are seeking an Enzymologist / Biological Chemist with deep expertise in enzyme kinetics, enzymatic transformations, and the reliable, repeatable production of complex enzymes—especially metalloenzymes and/or radical SAM systems. This role is highly process-driven: success depends on strict adherence to SOPs, careful documentation, tight batch-to-batch consistency, and a strong attention to detail. The ideal candidate will help power our high-throughput screening (HTS) engine by consistently generating active enzyme lots, screening enzyme variants, and implementing quality controls that ensure reproducible performance across campaigns.
Familiarity with ribosomally synthesized and post-translationally modified peptides (RiPPs), radical SAM enzymes, and anaerobic workflows is strongly preferred. Experience with computational protein design (e.g., RFDiffusion, ProteinMPNN) and genome mining / bioinformatics is a plus.
Qualifications: