
Algen Bio is revolutionizing therapeutic drug discovery by leveraging advanced CRISPR gene-modulation and AI. Their proprietary AlgenCRISPR system enables precise gene modulation, powering the AlgenBrain platform to industrialize single-cell, combinatorial gene modulation. This platform utilizes deep learning models trained on vast datasets of gene expression changes to predict RNA signaling networks and uncover disease-driving pathways. Originating from the lab of CRISPR pioneer Jennifer Doudna, Algen Bio aims to accelerate the identification of impactful therapeutic endpoints for complex diseases.

Algen Bio is revolutionizing therapeutic drug discovery by leveraging advanced CRISPR gene-modulation and AI. Their proprietary AlgenCRISPR system enables precise gene modulation, powering the AlgenBrain platform to industrialize single-cell, combinatorial gene modulation. This platform utilizes deep learning models trained on vast datasets of gene expression changes to predict RNA signaling networks and uncover disease-driving pathways. Originating from the lab of CRISPR pioneer Jennifer Doudna, Algen Bio aims to accelerate the identification of impactful therapeutic endpoints for complex diseases.
Sector: Biotechnology — therapeutic discovery
Core tech: Proprietary AlgenCRISPR gene-modulation + AlgenBrain AI models
Scientific origin: Research originating from Jennifer Doudna's lab (UC Berkeley)
Headquarters: San Francisco, California, United States
Employees (approx.): 14
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Therapeutic target discovery and decoding functional gene networks in complex diseases.
2018
Biotechnology
Crunchbase lists two funding rounds and a Seed as the most recent; company-reported investors include Viking, Cota Capital, Draper, Illumina Accelerator, Rebel Fund, Sequoia Capital, Y Combinator and others.
“Company lists strategic investors including Viking, Cota Capital, Draper, Illumina Accelerator, Y Combinator and Rebel; Crunchbase reports additional investors including Sequoia Capital and Viking.”
Company Description
Algen is a precision medicine company harnessing the power of CRISPR and functional genomics to transform drug discovery and development. A spin-out from the laboratory of Nobel Laureate Dr. Jennifer Doudna, Algen was founded at the forefront of gene-editing innovation. We combine cutting-edge CRISPR technologies with advanced computational approaches to systematically modulate disease biology at scale and accelerate the path to effective treatments. Join us in redefining what's possible in drug discovery.
Position Summary
We are seeking an experienced Associate Director of Translational Medicine
with deep expertise in immunology and oncology
to lead translational strategy across our preclinical-stage programs. This individual will serve as a critical bridge between discovery, clinical development, business development and external partners, ensuring mechanistic insights and biomarker strategies are effectively integrated into early-phase trials. This is a high-impact leadership role requiring a blend of scientific rigor, strategic thinking, and a tech-enabled, multidisciplinary approach to drug development .
Key Responsibilities
Qualifications
Education & Experience: MD or MD/PhD with 5+ years in translational medicine or early drug development, including 3+ years in a Biotech/Pharma environment
Preferred
Clinical Depth: Deep expertise in Phase 0–2 clinical trial methodology and familiarity with GCP and human research regulations
Immunology: Advanced experience in immunology-specific drug discovery and development, with a primary focus on inflammatory diseases
Oncology: Expert knowledge of tumor biology and the tumor microenvironment; demonstrated success integrating biomarkers and correlative science into clinical trials
Communication:
Executive presence and the ability to act as a high-level liaison between internal teams and external partners