Ob Summary Iambic Therapeutics is seeking an Associate Director to lead drug metabolism and pharmacokinetics (DMPK) strategies across discovery and preclinical development programs at Iambic. The role focuses on designing and executing integrated ADME/PK strategies to support program progression, inform key decisions, and enable IND submissions. The Associate Director will represent DMPK on cross-functional teams and collaborate closely with internal scientists and external CRO partners to plan, execute, and interpret studies. This position will be on-site at our San Diego Headquarters.

Key Responsibilities

• Support the design and implementation of DMPK strategies to advance discovery and development programs
• Plan, execute and interpret DMPK studies to support progression of therapeutic candidates across discovery and early development
• Collaborate with cross-functional teams (e.g., medicinal chemistry, biology, CMC, clinical) to provide DMPK insights and support project decisions
• Apply AI-driven tools and computational methods to improve DMPK strategy, enable predictive ADME/PK assessments, and accelerate data-driven decision-making across discovery and preclinical programs
• Provide input to address ADME /PK-related issues during lead optimization
• Oversee external ADME/PK and PK/PD studies, including coordination with CROs and data review
• Prepare DMPK summaries and supporting documentation for regulatory submissions (e.g. IND, IB)
• Interpret ADME/PK data and communicate findings and recommendations to project teams
• Stay current with advances in DMPK, PBPK, PK/PD, and regulatory guidelines.
• Ensure studies are conducted in compliance with applicable regulatory and quality standards

Qualifications

• PhD in relevant field such as Pharmacology, Biochemistry, Chemistry, Biology or related discipline; B.S./M.S. with extensive experience
• 12+ years of experience in the pharmaceutical or biotechnology industry, with a focus on DMPK, including at least 3 years of leadership experience in DMPK.
• Proven experience in designing, conducting, and interpreting DMPK studies supporting small molecule oncology programs.
• Experience with preparation of the DMPK sections of regulatory documents, (e.g., IND, IB, briefing document) is required.
• Hands-on experience with PBPK, PK/PD modeling, including the use of software tools such as Phoenix, GastroPlus, is highly desirable

About Iambic Therapeutics Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

Pay And Benefits We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.