The successful candidate will utilize the Genesis Molecular AI platform and guide medicinal chemistry efforts to drug discovery programs from Hit ID through candidate nomination. They will collaborate and/or lead multidisciplinary drug discovery projects and be responsible for shaping medicinal chemistry strategy on those projects. The candidate will be expected to be a medicinal chemistry leader and strong communicator.

What You Will Do (Key Responsibilities)

• Formulate medicinal chemistry strategies and utilize the Genesis platform to execute drug discovery programs from Hit ID through candidate nomination.
• Use Structure-Based Drug Design (SBDD) principles, optimize physiochemical properties, interpret in vitro and in vivo ADME/PK/Toxicology data, and understand in vitro and in vivo biology data to drive programs.
• Use data visualization software and metric based analysis to form medicinal chemistry hypotheses and prioritize strategies.
• Communicate and work with industry collaborators on drug discovery projects.
• Work with other drug discovery disciplines (biology, DMPK, software engineers, computational chemists) to drive hypothesis driven decisions, improve the platform and contribute to the scientific excellence of the company.
• Communicate and engage regularly with project team members and management.

What You’ll Bring

• PhD in synthetic organic chemistry or medicinal chemistry with at least 8 years of industrial drug discovery experience OR
• MS in synthetic organic chemistry with at least 14 years of industrial drug discovery experience.
• Expert medicinal chemistry knowledge with SBDD and physical property-based optimization of drug-like space.
• Expert and metric-based and data visualization to drive prioritization and efficiency.
• Strong communication skills, both in informal team settings as well as professional presentations.
• Expert synthetic chemistry knowledge and problem-solving skills.

What We Offer

• Competitive Pay
• Stock Option Eligibility
• 401(k) Plan
• Open PTO Policy
• Paid Company Holidays
• Free lunch and snacks at our offices
• Health Care Plan, including Medical, Dental, and Vision, fully covered for the employees

About Genesis Molecular AI Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company’s generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.

Genesis is headquartered in San Mateo, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.