
UpSurgeOn is a MedTech company focused on enhancing surgical skills through advanced simulation technologies. They offer a range of products including Cranial Series, Spine Series, Skill Series, Fluorescence Series, Anatomy Series, and Lab-in-a-Box, which utilize mixed reality and AR/VR to provide life-like training environments. The company aims to make surgical excellence universally accessible by facilitating a transition to cadaver-free training. Founded by neurosurgeons Dr. Federico Nicolosi and Dr. Giannantonio Spena, UpSurgeOn operates globally, serving trainees, scientific institutions, and MedTech companies. They have expanded into various surgical disciplines beyond neurosurgery, including ENT, spinal surgery, and plastic surgery. The company has secured grants, filed patents, and partnered with entities like Inovus Medical, demonstrating a strong focus on innovation and scientific validation.

UpSurgeOn is a MedTech company focused on enhancing surgical skills through advanced simulation technologies. They offer a range of products including Cranial Series, Spine Series, Skill Series, Fluorescence Series, Anatomy Series, and Lab-in-a-Box, which utilize mixed reality and AR/VR to provide life-like training environments. The company aims to make surgical excellence universally accessible by facilitating a transition to cadaver-free training. Founded by neurosurgeons Dr. Federico Nicolosi and Dr. Giannantonio Spena, UpSurgeOn operates globally, serving trainees, scientific institutions, and MedTech companies. They have expanded into various surgical disciplines beyond neurosurgery, including ENT, spinal surgery, and plastic surgery. The company has secured grants, filed patents, and partnered with entities like Inovus Medical, demonstrating a strong focus on innovation and scientific validation.
Founded: 2017
Headquarters: Milan, Italy
Product focus: Cadaver-free surgical simulation (physical simulators, AR/VR, mixed reality)
Founders: Dr. Federico Nicolosi; Dr. Giannantonio Spena
Distribution: Products sold in 99–110+ countries
Recent financing: Series A closed Feb 2, 2022
Surgical education and skills assessment; reducing reliance on cadaver labs and improving realistic, repeatable training environments.
2017
MedTech / Surgical simulation
Company described the 2022 round as a capital increase involving industrial investor Guala Dispensing Group.