
Unnatural Products is a California-based biotech company pioneering a novel drug discovery platform that engineers synthetic macrocycles to target complex, traditionally undruggable proteins. Their AI-enhanced platform designs, synthesizes, and screens cyclic peptide macrocycles that combine the cell permeability and oral bioavailability of small molecules with the specificity of biologics. This innovative approach addresses about 70% of drug targets that are inaccessible to conventional small molecules and biologics, positioning the company at the forefront of next-generation therapeutics. Their technology has attracted significant partnerships, including a $220M deal with Merck & Co., underscoring their market traction and potential to transform medicine by enabling treatments for hard-to-drug targets.

Unnatural Products is a California-based biotech company pioneering a novel drug discovery platform that engineers synthetic macrocycles to target complex, traditionally undruggable proteins. Their AI-enhanced platform designs, synthesizes, and screens cyclic peptide macrocycles that combine the cell permeability and oral bioavailability of small molecules with the specificity of biologics. This innovative approach addresses about 70% of drug targets that are inaccessible to conventional small molecules and biologics, positioning the company at the forefront of next-generation therapeutics. Their technology has attracted significant partnerships, including a $220M deal with Merck & Co., underscoring their market traction and potential to transform medicine by enabling treatments for hard-to-drug targets.
Founded: 2017
Headquarters: Santa Cruz, California
Tech: AI-driven platform for synthetic macrocyclic peptide therapeutics
Recent funding: Series A closed Dec 19, 2023
Notable partner/investor: Merck Global Health Innovation Fund
Drug discovery for traditionally undruggable proteins using synthetic macrocycles.
2017
Biotechnology
Seed round reported in September 2019
Series A closed Dec 19, 2023
“Backed by institutional investors including Artis Ventures and Merck Global Health Innovation Fund; lists multiple additional venture investors”