
Sixfold Bio is revolutionizing RNA therapies by addressing the critical challenge of RNA delivery. Their platform, inspired by nature and powered by AI, utilizes a proprietary programmable RNA tag called Mergo®. Mergo® encodes RNA modifications to influence delivery destination, enabling targeted delivery of RNA to cell types beyond the liver, which currently remains untargetable for most RNA therapeutics. The company leverages a combination of machine learning for Mergo design, innovative chemistry and automation for rapid production, and high-throughput testing for optimization. This approach dramatically reduces the time and cost of data acquisition in developing new RNA delivery systems. Their solution is poised to unlock the full potential of RNA medicine by expanding therapeutic targeting.

Sixfold Bio is revolutionizing RNA therapies by addressing the critical challenge of RNA delivery. Their platform, inspired by nature and powered by AI, utilizes a proprietary programmable RNA tag called Mergo®. Mergo® encodes RNA modifications to influence delivery destination, enabling targeted delivery of RNA to cell types beyond the liver, which currently remains untargetable for most RNA therapeutics. The company leverages a combination of machine learning for Mergo design, innovative chemistry and automation for rapid production, and high-throughput testing for optimization. This approach dramatically reduces the time and cost of data acquisition in developing new RNA delivery systems. Their solution is poised to unlock the full potential of RNA medicine by expanding therapeutic targeting.
Founded: 2017
Headquarters: White City, London
Focus: AI-enabled programmable RNA delivery platform (Mergo®) for siRNA and mRNA
Stage: Preclinical
Seed funding (announced): $10.5M USD total (seed round reported)
RNA therapeutics delivery—targeting specific cell types beyond liver for siRNA and mRNA medicines.
2017
Biotechnology
$10.5M USD (seed financing reported, including a second close)
Company reported a $10.5M USD seed financing (second close raised $2.2M USD).
Grant funding activity reported on Dec 2, 2021; company has also received public/non-dilutive funding (Innovate UK, European Commission).
Awarded Biomedical Catalyst funding from Innovate UK (~£0.89M / just over $1M) to support Mergo® development.
“Venture and public funders including Y Combinator, Cantos Ventures, Lombard Street Ventures, Pi Campus, Bossa Invest, Innovate UK and the European Commission”