
Pangea Bio develops small-molecule therapeutics for neurological and neuropsychiatric disorders by mining nature’s chemical space and human ethnobotanical evidence. The company combines AI-driven drug discovery with natural-product chemistry and preclinical pharmacology to identify and optimize TrkB-activating and other CNS-targeted molecules. It operates as a biotechnology research and drug-development organization (B2B) that offers research services and SaaS tools for pharmaceutical partners. Pangea’s scalable CNS pipeline is centered on nature-inspired compounds and includes lead asset OT-003, which is scheduled to enter Phase 1 studies in 2025. The approach targets large unmet needs in CNS disorders by integrating AI, ethnobotany, and traditional safety evidence to accelerate candidate selection.

Pangea Bio develops small-molecule therapeutics for neurological and neuropsychiatric disorders by mining nature’s chemical space and human ethnobotanical evidence. The company combines AI-driven drug discovery with natural-product chemistry and preclinical pharmacology to identify and optimize TrkB-activating and other CNS-targeted molecules. It operates as a biotechnology research and drug-development organization (B2B) that offers research services and SaaS tools for pharmaceutical partners. Pangea’s scalable CNS pipeline is centered on nature-inspired compounds and includes lead asset OT-003, which is scheduled to enter Phase 1 studies in 2025. The approach targets large unmet needs in CNS disorders by integrating AI, ethnobotany, and traditional safety evidence to accelerate candidate selection.
What they do: AI-driven biotech discovering nature-inspired CNS therapeutics
Headquarters: Sevenoaks, Kent, United Kingdom
Founded: 2021
Lead asset: OT-003 entering Phase 1 in 2025
Reported funding: Reported total ~$15M; investors include Empath Ventures, Eretz.bio, Globivest, Kadmos Capital, No Label Ventures, Seaside Ventures
Central nervous system and neuropsychiatric therapeutic development
2021
Biotechnology
Convertible-note entry recorded on company profile
Series A recorded on company profile
“Empath Ventures, Eretz.bio, Globivest, Kadmos Capital, No Label Ventures, Seaside Ventures”