
Matterworks makes complex biological data interpretable by converting mass spectrometry outputs into quantitative molecular readouts for life sciences applications. It does this through Pyxis, an AI-driven SaaS platform built on the company’s proprietary Large Spectral Model (LSM) and trained on extensive LC‑MS/MS (MS2) datasets to enable untargeted, absolute quantitation in minutes. The platform uses machine learning and spectral modeling to automate data processing and produce reproducible results without specialized manual workflows. Customers include life sciences researchers and biotech companies using the product for drug discovery, biomarker discovery, bioprocessing, and synthetic biology. Matterworks positions its technology as a scalable analytical layer that integrates with existing experimental mass‑spectrometry pipelines.

Matterworks makes complex biological data interpretable by converting mass spectrometry outputs into quantitative molecular readouts for life sciences applications. It does this through Pyxis, an AI-driven SaaS platform built on the company’s proprietary Large Spectral Model (LSM) and trained on extensive LC‑MS/MS (MS2) datasets to enable untargeted, absolute quantitation in minutes. The platform uses machine learning and spectral modeling to automate data processing and produce reproducible results without specialized manual workflows. Customers include life sciences researchers and biotech companies using the product for drug discovery, biomarker discovery, bioprocessing, and synthetic biology. Matterworks positions its technology as a scalable analytical layer that integrates with existing experimental mass‑spectrometry pipelines.
Founded: 2019
Headquarters: Somerville, Massachusetts, United States
Product: AI-driven cloud platform (Pyxis) and Large Spectral Model for automated metabolomics/LC-MS analysis
Customers: Life sciences researchers and biotech companies (drug discovery, biomarker discovery, bioprocessing, synthetic biology)
Latest round: Series A (Jun 3, 2025)
Total funding (reported): $13.75M (Crunchbase) — Dealroom reports $15.9M
Metabolomics and mass-spectrometry data interpretation for life-sciences research and biotech applications.
2019
Biotechnology
Series A announced in June 2025; participation from Pillar VC and Germin8 Ventures reported.
“Raised a Series A with participation from multiple institutional investors including Lewis & Clark Capital, OMX Ventures, Pillar VC, Germin8 Ventures, Intermountain Ventures, Tarsadia Investments”