
Locus Biosciences is a precision medicine company revolutionizing the treatment of bacterial infections and addressing unmet medical needs in immunology, oncology, and CNS disorders through engineered bacteriophage products. Their core technology, the LOCUS platform, integrates advanced robotics, automated biobanking, AI-driven cocktail prediction, and synthetic biology to engineer highly effective phage cocktails. This platform allows for precise targeting of pathogenic bacteria while preserving the beneficial microbiome. Locus emphasizes its clinical success, world-class viral vector manufacturing facility for cGMP clinical trial material, and its AI-driven approach which uses machine learning for lead optimization and natural language processing on genomic data to identify optimal phage insertion sites for enhanced payload expression and stability. Their lead therapeutic, LBP-EC01, is in clinical trials for E. coli infections.

Locus Biosciences is a precision medicine company revolutionizing the treatment of bacterial infections and addressing unmet medical needs in immunology, oncology, and CNS disorders through engineered bacteriophage products. Their core technology, the LOCUS platform, integrates advanced robotics, automated biobanking, AI-driven cocktail prediction, and synthetic biology to engineer highly effective phage cocktails. This platform allows for precise targeting of pathogenic bacteria while preserving the beneficial microbiome. Locus emphasizes its clinical success, world-class viral vector manufacturing facility for cGMP clinical trial material, and its AI-driven approach which uses machine learning for lead optimization and natural language processing on genomic data to identify optimal phage insertion sites for enhanced payload expression and stability. Their lead therapeutic, LBP-EC01, is in clinical trials for E. coli infections.
Stage: Clinical-stage
Lead asset: LBP-EC01 (E. coli)
Platform: CRISPR-Cas3–enhanced bacteriophage therapeutics (crPhage™) with AI/robotics-driven discovery
Founded: 2015
Recent financing: $35M financing announced May 18, 2022
Bacterial infections and related unmet needs across infectious disease, immunology, oncology, and CNS disorders.
2015
Biotechnology
19,000,000
Series A closed Nov 14, 2017; additional investors included Tencent Holdings, Abstract Ventures and others.
35,000,000
Completed $35M financing which included Series B equity and conversion of an earlier convertible note.
25,000,000
Secured a credit facility of up to $25M for milestone-based drawdowns.
20,000,000
Exclusive collaboration with upfront payment and potential milestone payments reported under the deal.
“Artis Ventures, Tencent Holdings, Abstract Ventures, Viking Global Investors, Johnson & Johnson Innovation, Hercules Capital, CARB-X, BARDA, Discovery Innovations”