
Junevity develops therapeutics that aim to restore youthful cellular function and extend healthspan by resetting age-altered transcriptional programs. The company uses its RESET Platform — combining large-scale human transcriptomics, spatial transcriptomics, bioinformatics, and AI/ML — to identify transcription factor targets and design siRNA-based cell reprogramming therapeutics. Junevity's pipeline includes programs for metabolic and neurodegenerative indications and age-related diseases such as Type 2 Diabetes, Obesity, Osteoarthritis, and Sarcopenia. Operating as a biotechnology company serving research and drug-development partners, it applies computational and molecular tools to translate human disease data into first-in-class siRNA therapeutics.

Junevity develops therapeutics that aim to restore youthful cellular function and extend healthspan by resetting age-altered transcriptional programs. The company uses its RESET Platform — combining large-scale human transcriptomics, spatial transcriptomics, bioinformatics, and AI/ML — to identify transcription factor targets and design siRNA-based cell reprogramming therapeutics. Junevity's pipeline includes programs for metabolic and neurodegenerative indications and age-related diseases such as Type 2 Diabetes, Obesity, Osteoarthritis, and Sarcopenia. Operating as a biotechnology company serving research and drug-development partners, it applies computational and molecular tools to translate human disease data into first-in-class siRNA therapeutics.
Founded: 2023 (out of UCSF)
Headquarters: San Francisco, CA
Tech / Modality: siRNA-based cell reprogramming (RESET platform)
Lead program focus: Metabolic disease (JUN_01) and neurodegeneration
Seed funding: $20M total seed (expanded from $10M)
Age-related diseases and loss of youthful cellular transcriptional programs (e.g., Type 2 Diabetes, Obesity, Osteoarthritis, Sarcopenia, neurodegeneration).
2023
Biotechnology
$10,000,000
Initial seed announced Feb 13, 2025.
$10,000,000
Expanded seed financing announced Dec 3, 2025, bringing total to $20M.
“Investors include venture firms (Goldcrest Capital, Godfrey Capital) alongside biotech veterans, physicians, tech entrepreneurs and hedge fund managers”