
HotSpot Therapeutics discovers allosteric medicines that modulate natural regulatory hotspots on proteins to treat cancer, autoimmune and other diseases. The company uses its proprietary Smart Allostery platform, combining structure-function analysis, pharmacology, medicinal chemistry and AI, to identify and design small molecules that bind regulatory pockets remote from active sites. HotSpot operates as a biotechnology company focused on drug discovery and development, and pursues collaborations and licensing with pharmaceutical and biotechnology partners. Its approach aims to produce highly selective, drug-like therapeutics for diseases with limited treatment options. The technology has been applied across oncology and immunology programs and is supported by preclinical data and scientific presentations.

HotSpot Therapeutics discovers allosteric medicines that modulate natural regulatory hotspots on proteins to treat cancer, autoimmune and other diseases. The company uses its proprietary Smart Allostery platform, combining structure-function analysis, pharmacology, medicinal chemistry and AI, to identify and design small molecules that bind regulatory pockets remote from active sites. HotSpot operates as a biotechnology company focused on drug discovery and development, and pursues collaborations and licensing with pharmaceutical and biotechnology partners. Its approach aims to produce highly selective, drug-like therapeutics for diseases with limited treatment options. The technology has been applied across oncology and immunology programs and is supported by preclinical data and scientific presentations.
Founded: 2017
Headquarters: Boston, Massachusetts
Focus: Allosteric small-molecule therapies for cancer and autoimmune disease
Proprietary platform: Smart Allostery / SpotFinder
Clinical asset: HST-1011 (oral allosteric CBL-B inhibitor) in clinical development
Total funding (reported): USD 210,000,000
Drug discovery and development for oncology and immunology using allosteric modulation of proteins.
2017
Biotechnology Research
USD 45,000,000
USD 65,000,000
USD 100,000,000
“Atlas Venture; Sofinnova Partners; S.R. One; Pivotal bioVenture Partners; Tekla Capital Management; MRL Ventures Fund; Solasta Ventures; Brace Pharma; LSP; B Capital; Monashee; CaaS Capital Management; Revelation Partners”
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