
Highland Instruments is a neurotechnology company pioneering ESStim™, a non-invasive neuromodulation platform developed to treat chronic pain, neurodegenerative diseases like Parkinson's, and psychiatric disorders such as Opioid Use Disorder. Founded by scientists from Harvard Medical School and MIT, the company leverages a proprietary ElectroSonic Stimulation (ESStim™) technology that combines electromagnetic and ultrasonic fields for enhanced and focused neural stimulation. ESStim™ is protected by patents and has shown significant benefits in clinical trials for Parkinson's Disease and Chronic Pain, with ongoing investigations for Opioid Use Disorder. Highland Instruments also holds intellectual property in artificial intelligence, imaging, wearable sensors, and human movement kinematics, aiming to provide a non-invasive alternative to medication and surgery for millions of patients.

Highland Instruments is a neurotechnology company pioneering ESStim™, a non-invasive neuromodulation platform developed to treat chronic pain, neurodegenerative diseases like Parkinson's, and psychiatric disorders such as Opioid Use Disorder. Founded by scientists from Harvard Medical School and MIT, the company leverages a proprietary ElectroSonic Stimulation (ESStim™) technology that combines electromagnetic and ultrasonic fields for enhanced and focused neural stimulation. ESStim™ is protected by patents and has shown significant benefits in clinical trials for Parkinson's Disease and Chronic Pain, with ongoing investigations for Opioid Use Disorder. Highland Instruments also holds intellectual property in artificial intelligence, imaging, wearable sensors, and human movement kinematics, aiming to provide a non-invasive alternative to medication and surgery for millions of patients.
Sector: Neurotechnology / Biotechnology
Core technology: ElectroSonic Stimulation (ESStim™) noninvasive neuromodulation
Clinical focus: Chronic pain, Parkinson's disease, opioid use disorder (investigational)
Headquarters: Braintree, Massachusetts, USA
Notable funder: MassVentures (grant)
Treatment of chronic pain, neurodegenerative movement disorders, and psychiatric disorders via noninvasive neuromodulation.
2007
Biotechnology
START Stage I grant awarded (recorded May 16, 2025)
“MassVentures (grant)”