
Genio Technologies provides a handheld device that rapidly identifies tissue molecular profiles to support intraoperative diagnostic decisions. The MasSpec Pen applies a microliter water droplet to tissue, transports the sample to a mass spectrometer, and uses AI/ML algorithms to classify proteins, lipids, and metabolites. The product combines mass spectrometry hardware, analytical chemistry, and machine learning into a point-of-need medical device integrated with surgical and pathology workflows. The technology is aimed at clinical and surgical teams to distinguish tumor from healthy tissue without labeling or tissue destruction.

Genio Technologies provides a handheld device that rapidly identifies tissue molecular profiles to support intraoperative diagnostic decisions. The MasSpec Pen applies a microliter water droplet to tissue, transports the sample to a mass spectrometer, and uses AI/ML algorithms to classify proteins, lipids, and metabolites. The product combines mass spectrometry hardware, analytical chemistry, and machine learning into a point-of-need medical device integrated with surgical and pathology workflows. The technology is aimed at clinical and surgical teams to distinguish tumor from healthy tissue without labeling or tissue destruction.
What they do: Handheld device (MasSpec Pen) that samples tissue and uses mass spectrometry + ML for intraoperative molecular diagnostics
Stage & funding: Seed stage; seed lead investor listed as i2E Management Company
Headquarters: Tulsa, Oklahoma (listed); alternate listing: Sunnyvale, California (Crunchbase)
Founded: 2019
Intraoperative tissue diagnostics; real-time tumor vs. healthy tissue identification
2019
Biotechnology
1250000
“i2E Management Company listed as lead investor”