
Cyrus Biotechnology is an AI-driven discovery company specializing in naturally existing proteins engineered into superior therapeutics using AI and deep mutagenesis. Their platform integrates novel algorithms and advanced laboratory methods to rapidly develop biologics, focusing on severe autoimmune diseases and therapeutic immuno cytokines. Key products include IdeS for IgG-driven autoimmune diseases, an IL-22 fusion protein for autoimmune gastrointestinal and metabolic indications, and a COVID-19 prophylaxis candidate effective against all variants. The company has over 30 discovery programs with partners and collaborations with top biotech firms, positioning it as a leader in AI-powered protein design for autoimmune therapeutics.

Cyrus Biotechnology is an AI-driven discovery company specializing in naturally existing proteins engineered into superior therapeutics using AI and deep mutagenesis. Their platform integrates novel algorithms and advanced laboratory methods to rapidly develop biologics, focusing on severe autoimmune diseases and therapeutic immuno cytokines. Key products include IdeS for IgG-driven autoimmune diseases, an IL-22 fusion protein for autoimmune gastrointestinal and metabolic indications, and a COVID-19 prophylaxis candidate effective against all variants. The company has over 30 discovery programs with partners and collaborations with top biotech firms, positioning it as a leader in AI-powered protein design for autoimmune therapeutics.
Focus: AI-driven computational protein design for therapeutic biologics (autoimmune diseases, therapeutic cytokines)
Product & pipeline: Cyrus Bench® (Rosetta-based SaaS); lead programs include IdeS (IgG depletion), an IL-22 fusion protein, and ACE2v2-Fc / COVID-19 prophylaxis candidate
Founding / origin: Founded 2014 as a spin-out from the University of Washington; David Baker listed as scientific co-founder & advisor
Funding: Disclosed financings: $8M Series A (Jul 2017) and $18M Series B (Dec 2021); total funding reported 46838168 USD
Team size: 23 employees (reported)
Computational protein design and discovery for therapeutic biologics, with emphasis on naturally occurring proteins, autoimmune diseases, and therapeutic cytokines.
2014
Biotechnology
$8M
Participation from OrbiMed Advisors, SpringRock Ventures, W Fund and individual investors.
$18M
Investors included OrbiMed Advisors, Trinity Ventures, Agent Capital, Yard Ventures, Washington Research Foundation, iSelect Fund, W Fund, family offices and individual investors; announced acquisition of Orthogonal Biologics and noted Selecta Biosciences as a strategic investor.
“Backed by biotech and tech investors including OrbiMed Advisors, Trinity Ventures, Agent Capital, Selecta Biosciences (strategic), Washington Research Foundation, iSelect Fund, W Fund, and others.”