
CircNova, Inc. is a biotechnology company leveraging its proprietary AI NovaEngine™ to generate, analyze, and identify circular RNA for therapeutic development. The company focuses on non-coding RNA targeting undruggable disease targets with major unmet clinical needs, developing a robust intellectual property portfolio for circRNA therapeutics. Their AI NovaEngine™ uses deep learning to predict circular RNA 3D structures, enabling revolutionary efficiencies in drug discovery, gene therapy, and biotechnology, particularly for diseases like Triple-negative Breast Cancer. CircNova operates with a mission to innovate RNA-based therapies, supported by continuous AI learning and novel data generation, positioning itself as a leader in RNA therapeutics with key partnerships and a diverse expert team.

CircNova, Inc. is a biotechnology company leveraging its proprietary AI NovaEngine™ to generate, analyze, and identify circular RNA for therapeutic development. The company focuses on non-coding RNA targeting undruggable disease targets with major unmet clinical needs, developing a robust intellectual property portfolio for circRNA therapeutics. Their AI NovaEngine™ uses deep learning to predict circular RNA 3D structures, enabling revolutionary efficiencies in drug discovery, gene therapy, and biotechnology, particularly for diseases like Triple-negative Breast Cancer. CircNova operates with a mission to innovate RNA-based therapies, supported by continuous AI learning and novel data generation, positioning itself as a leader in RNA therapeutics with key partnerships and a diverse expert team.
Founded: May 2023
Headquarters: Cambridge, Massachusetts (operational presence in Michigan)
Tech: NovaEngine AI for circular RNA therapeutics + in-house wet lab
Recent funding: $3.3M seed (announced Feb 21, 2025)
RNA therapeutics for diseases with major unmet clinical needs (including applications like triple-negative breast cancer).
2023
Biotechnology
$3.3M
Participation reported from Spark Capital, Michigan Rise, Invest Detroit, Kalamazoo Forward Ventures, Union Heritage Capital, Dug Song and others.
Michigan Rise investment reported as part of the company's pre-seed financing.