
BlackThorn Therapeutics develops precision medicines that target dysfunctional brain circuits to treat central nervous system and neurobehavioral disorders. The company applies advances in computational and clinical neuroscience through a proprietary computational platform to identify novel targets, small-molecule drug candidates, and biologically defined patient subgroups most likely to respond. It is a clinical-stage biopharmaceutical company combining neuroscience data, machine learning models, and biomarker-driven patient stratification. BlackThorn focuses on developing therapeutics for CNS indications and advancing candidates through clinical trials. Its approach positions the company to address unmet needs in neuropsychiatry by linking neuroscience-derived targets to precision drug development.

BlackThorn Therapeutics develops precision medicines that target dysfunctional brain circuits to treat central nervous system and neurobehavioral disorders. The company applies advances in computational and clinical neuroscience through a proprietary computational platform to identify novel targets, small-molecule drug candidates, and biologically defined patient subgroups most likely to respond. It is a clinical-stage biopharmaceutical company combining neuroscience data, machine learning models, and biomarker-driven patient stratification. BlackThorn focuses on developing therapeutics for CNS indications and advancing candidates through clinical trials. Its approach positions the company to address unmet needs in neuropsychiatry by linking neuroscience-derived targets to precision drug development.
Founded: 2015
Headquarters: San Francisco, California, USA
Focus: Precision therapeutics for CNS and neurobehavioral disorders using computational neuroscience and AI
Clinical stage: Yes
Notable financing: Series B $76M (Jun 13, 2019); total reported funding ~$138M
Central nervous system (CNS) and neurobehavioral disorders; neuropsychiatry.
2015
Biotechnology
76,000,000 USD
Series B participation included GV (Google Ventures), Johnson & Johnson Innovation, Polaris Partners, ARCH Venture Partners and others.
~40,000,000 USD
Series A activity reported around 2016–2017.
“ARCH Venture Partners; GV (Google Ventures); Johnson & Johnson Innovation; Polaris Partners; The Scripps Research Institute; Biomatics Capital Partners; Vertex Ventures HC; Mercury”