
Avenue Biosciences helps biopharmaceutical developers increase protein production yields and product quality to make difficult‑to‑express biologics manufacturable. The company uses a proprietary protein engineering platform that combines machine learning and AI with synthetic biology, high‑throughput chemistry, and bioinformatics to optimize N‑terminal signal peptides for mammalian expression systems. Its technology is offered as services for biotech and biopharma customers and is compatible with diverse modalities including mRNA therapies and synthetic proteins. Founded on research from the University of Helsinki and operating between San Francisco and Helsinki, Avenue reduces time‑to‑market and production costs for therapeutic development.

Avenue Biosciences helps biopharmaceutical developers increase protein production yields and product quality to make difficult‑to‑express biologics manufacturable. The company uses a proprietary protein engineering platform that combines machine learning and AI with synthetic biology, high‑throughput chemistry, and bioinformatics to optimize N‑terminal signal peptides for mammalian expression systems. Its technology is offered as services for biotech and biopharma customers and is compatible with diverse modalities including mRNA therapies and synthetic proteins. Founded on research from the University of Helsinki and operating between San Francisco and Helsinki, Avenue reduces time‑to‑market and production costs for therapeutic development.
What they do: Optimize N‑terminal signal peptides and the secretory pathway to boost protein expression and quality using ML, synthetic biology and high‑throughput chemistry
Headquarters / footprint: Transatlantic — Helsinki and San Francisco Bay Area
Stage / funding: Seed; total disclosed funding $8.7M (2024–2026)
Founded: 2024 (originating from University of Helsinki research)
Biotherapeutic manufacturing: low expression yields and poor product quality for difficult‑to‑express biologics.
2024
Biotechnology
2,500,000
Participation from Inventure and US angel investors
5,700,000
Support from existing investors Voima Ventures, Inventure, University of Helsinki and Dimerent; brings total disclosed funding to $8.7M
“Early‑stage institutional backers (Voima Ventures, Inventure) with later participation from regional funds and university investor”