
Aulos Bioscience is a biotechnology company focused on revolutionizing cancer care through the development of a novel immune-activating antibody therapeutic, AU-007, designed to transform the treatment of solid tumors. Leveraging artificial intelligence and machine learning, the company computationally designs human monoclonal antibodies that precisely target IL-2 interactions to shift immune activity towards activation and away from suppression, aiming to overcome limitations and toxic side effects of existing IL-2 therapies. Their lead product candidate, AU-007, is in Phase 2 clinical trials for advanced solid tumors including melanoma and renal cell carcinoma, demonstrating a well-tolerated safety profile and promising anti-tumor activity. The company is co-founded by Biolojic Design and ATP, backed by $60 million in Series A funding, and is positioned as a changemaker in immuno-oncology with a unique approach to cancer immunotherapy.

Aulos Bioscience is a biotechnology company focused on revolutionizing cancer care through the development of a novel immune-activating antibody therapeutic, AU-007, designed to transform the treatment of solid tumors. Leveraging artificial intelligence and machine learning, the company computationally designs human monoclonal antibodies that precisely target IL-2 interactions to shift immune activity towards activation and away from suppression, aiming to overcome limitations and toxic side effects of existing IL-2 therapies. Their lead product candidate, AU-007, is in Phase 2 clinical trials for advanced solid tumors including melanoma and renal cell carcinoma, demonstrating a well-tolerated safety profile and promising anti-tumor activity. The company is co-founded by Biolojic Design and ATP, backed by $60 million in Series A funding, and is positioned as a changemaker in immuno-oncology with a unique approach to cancer immunotherapy.
Sector: Immuno-oncology / Biotechnology
Lead program: AU-007 (imneskibart) — computationally designed IL-2–targeting monoclonal antibody
Clinical stage: Phase 2 portion of a Phase 1/2 clinical program
Headquarters: Larkspur, California
Funding: $60M total Series A commitments (initial $40M + $20M extension) led by Apple Tree Partners
Immuno-oncology; improving cytokine (IL-2) therapies for solid tumors.
2020
Biotechnology
$40,000,000
Initial Series A commitment to advance lead molecule from preclinical through clinical proof of concept.
$20,000,000
Extension financing to advance AU-007 through a Phase 2 trial.
“Led and primarily funded by Apple Tree Partners”